Rawalpindi Medical University

Trends in perioperative mortality in the United States: A 25 year retrospective analysis

Background Perioperative mortality, defined as death within 30 days of surgery, is a significant global health concern. Despite improvements in surgical practices and anesthesia care, it continues to account for millions of deaths annually. This study examines trends in periopera...

A public health concern: Rising cardiovascular burden

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Real-world safety and effectiveness of empagliflozin (Diampa®) alone or in combination with metformin (Diampa-M®) in patients with type 2 diabetes mellitus in Pakistan: a multicenter observational study

Abstract Background Type 2 diabetes mellitus (T2DM) is a growing public health challenge in Pakistan, where poor glycemic control is common. Sodium–glucose co-transporter 2 (SGLT2) inhibitors, such as empagliflozin, have shown glycemic, cardiovascular, and renal benefits in contr...

Association of Preexisting Atrial Fibrillation or Flutter With 30-Day Outcomes After Septic Shock: A Propensity-Matched Federated Database Study

Preexisting atrial fibrillation (AF) or atrial flutter may impair cardiovascular reserve during septic shock, potentially leading to worse clinical outcomes; however, its independent association with short-term outcomes remains uncertain. Using the TriNetX U.S. Collaborative Netw...

Post-Procedural Angiography-Based Physiological Indices and Clinical Outcomes After Drug-Coated Balloon Treatment of In-Stent Restenosis

Drug-coated balloons (DCBs) represent an accepted approach for in-stent restenosis (ISR); however, post-procedural predictors for risk stratification remain limited. Angiography-based physiological parameters, including quantitative flow ratio (QFR), microvascular QFR (μQFR), and...

Angiography-Derived vs Wire-Based Physiological Assessment in Coronary Artery Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This study aimed to determine whether angiography-based physiological assessment yields clinical outcomes comparable to those of conventional wire-based pressure measurements in patients with coronary artery disease (CAD) undergoing evaluation of intermediate coronary stenoses. A...

Superior sagittal sinus thrombosis in hemoglobin S–D disease with acute pyogenic meningitis: a rare case report

Cerebral venous sinus thrombosis (CVST) involving the superior sagittal sinus with associated cerebral infarction is an exceptionally rare neurological complication of hemoglobin S–D disease. The heterogeneity of clinical manifestations, overlapping infective and hematologic feat...

Efficacy of rituximab plus lenalidomide regimens in follicular lymphoma: a meta-analysis of randomized controlled trials

Follicular lymphoma (FL) is an incurable, indolent non-Hodgkin lymphoma with a high relapse rate despite effective chemoimmunotherapy. Lenalidomide, an immunomodulatory agent, in combination with rituximab (R²), has been evaluated as an alternative to chemoimmunotherapy and to ot...

Synthesis of polyhydroquinoline derivatives as potent antidiabetic and antioxidant agents: in vitro biological activities and computational studies

Aims Diabetes mellitus (DM) is a severe metabolic disease characterized by increased blood glucose levels due to reduced insulin action or secretion. This study aimed to synthesize new polyhydroquinoline (PHQ)-based acyl hydrazide derivatives and assess their potential as dual in...

AI-based thermal management analysis of electronic devices using Cu–Fe3O4–SiO2 ternary hybrid nanofluid over a rotating disk with Hall current and dissipation

Effective thermal management is critical challenge in advanced energy units and high-performance electronics, where escalating thermal dissipation need efficient energy strategies and sophisticated cooling mechanisms that can improve energy management. The study investigates enha...

Pulsed Field Versus Cryoballoon Ablation for Atrial Fibrillation: A Systematic Review and Meta-Analysis

In the treatment of atrial fibrillation (AF), cryoballoon ablation (CBA) is associated with a high incidence of pulmonary vein reconnection, potentially limiting long-term efficacy. Pulsed field ablation (PFA) has emerged as a promising alternative with the potential for improved...

Blinatumomab versus chemotherapy in pediatric B-ALL: A meta-analysis of randomized trials in relapsed and high-risk frontline disease

BACKGROUND: B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric cancer, comprising almost 25 % of childhood malignancies. Despite advances in chemotherapy, relapse remains a major cause of treatment failure, particularly in high-risk patients. Blinatumomab, a...