Rashid Latif Medical College

Functional Outcomes Following Cemented Bipolar Hemiarthroplasty Versus Total Hip Arthroplasty for Displaced Femoral Neck Fractures in Older Adults: A Retrospective Cohort Study

Background: Older persons frequently sustain femoral neck fractures, which are linked to significant morbidity and functional loss. Although total hip arthroplasty (THA) and cemented bipolar hemiarthroplasty (CBH) are common treatment choices, there is ongoing debate regarding wh...

Efficacy and Safety of Argatroban as an Adjunct to Antiplatelet Therapy in Ischemic Stroke: An Updated Systematic Review and Meta-analysis

Abstract Introduction Acute ischemic stroke (AIS) is a life-threatening condition. Argatroban can limit thrombus progression and improve AIS’s functional outcomes. This study assessed the efficacy and safety of argatroban in combination with antiplatelet therapy compared to contr...

In silico AI-guided de novo design of S1PR1-targeting ligands from a siponimod scaffold for angiogenesis and fat-cartilage graft survival

Fat cartilage graft survival is frequently limited by insufficient early vascularization, resulting in ischemia and partial tissue loss. Sphingosine-1-phosphate receptor 1 (S1PR1) is a key regulator of endothelial barrier integrity, vascular maturation, and controlled angiogenic...

Comparative effect of Sahrmann exercises and core stabilization exercises on low back pain in individuals with lumbar lordosis

Objectives: The objective of the study is to evaluate the effects of Sahrmann versus core stabilization exercises on pain and functional disability in low back pain (LBP) patients with lumbar hyperlordosis. Methods: A single-blinded randomized clinical trial was conducted at Arif...

Efficacy of rituximab plus lenalidomide regimens in follicular lymphoma: a meta-analysis of randomized controlled trials

Follicular lymphoma (FL) is an incurable, indolent non-Hodgkin lymphoma with a high relapse rate despite effective chemoimmunotherapy. Lenalidomide, an immunomodulatory agent, in combination with rituximab (R²), has been evaluated as an alternative to chemoimmunotherapy and to ot...