Rambam Health Care Campus

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

OBJECTIVE: Real-world initial treatment strategies in SSc-PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. METHODS: We analysed treatment-naïve SSc-PAH patients in EUSTAR...

Executive-Function Networks in Listening and Reading Comprehension: A Comparison of Children With SeLECTS, Children With Reading Difficulties, and Typical Readers

Children with Self-Limited Epilepsy with Centro-Temporal Spikes (SeLECTS) display deficits in both listening and reading comprehension, as well as in executive functions (EFs). The aim of the current study was to investigate differences in EF involvement—operationalized as the co...

Orbital Fractures at a Level 1 Trauma Center: A Retrospective Epidemiological Analysis of 1489 Consecutive Fracture Records

Objectives: Comprehensive epidemiological data on orbital fractures from large full-spectrum series remain scarce. We describe the demographics, mechanisms, fracture anatomy, CT-derived defect morphometry, and clinical findings at presentation of orbital fractures managed at a le...

Infections in MonumenTAL-1: a plain language summary of talquetamab treatment for relapsed/refractory multiple myeloma

Plain Language SummaryWhat is this summary about?This summary describes infection and immune cell data of participants receiving talquetamab for relapsed/refractory multiple myeloma (RRMM) in the MonumenTAL-1 study.What were the results?Almost 60% of participants receiving talque...

Closing the gap between non-measurable residual disease and true absence of minimal residual disease

Not available.

A Badge-Sized Cognitive Aid and Pediatric Point-of-Care Ultrasound Integration in the Emergency Department

OBJECTIVES: Point-of-care ultrasound (POCUS) is widely taught in pediatric emergency medicine, yet achieving confident, independent bedside scanning remains difficult for many trainees. To bridge this gap between knowledge and real-time performance, we evaluated a badge-sized, we...

A New Case of Lethal Congenital Contracture Syndrome Type 3 With Hyperinsulinism and Optic Atrophy

ABSTRACT Lethal congenital contracture syndrome 3 (LCCS3, MIM #611369) is a rare autosomal recessive neuromuscular disorder caused by biallelic loss‐of‐function (LOF) variants in PIP5K1C , reported in only two families to date. It typically presents with severe fetal akinesia, ar...

Cefepime and Mortality

Importance Cefepime is recommended for the treatment of febrile neutropenia and gram-negative infections at moderate risk of ampicillin resistance locus C β-lactamase production. Concerns regarding cefepime’s safety have been raised in the literature without firm conclusions. Obj...

Non‐contrast CT Markers of Hematoma Expansion and Andexanet Response in Factor Xa Inhibitor‐Associated Intracerebral Hemorrhage: An Analysis from ANNEXa ‐I Trial

In this post hoc analysis of the ANNEXa-I trial (n = 434), we evaluated non-contrast computed tomography (NCCT) markers of hematoma expansion (HE) in factor Xa inhibitor (FXai) -associated intracerebral hemorrhage (ICH). At least one NCCT marker was present in 72.1%, and HE (≥12....

From Rapid Progression to Long-Lasting Complete Response: A Wide Range of Ripretinib Activity for Metastatic GIST—A Real-World Cohort

Background: Ripretinib, a switch-control kinase inhibitor approved for advanced gastrointestinal stromal tumor (GIST), inhibits primary and secondary KIT and PDGFRA mutations. Real-world data from Western and Middle Eastern populations remain limited. We report outcomes from a mo...

In vitro evaluation of vancomycin-loaded Marlex mesh against staphylococci isolated from periprosthetic joint infection

Aims Extensor mechanism disruption is a major complication following total knee arthroplasty, with treatment often consisting of extensor mechanism reconstruction utilizing monofilament polypropylene mesh (Marlex mesh, C. R. Bard, Inc). Infection following this procedure is devas...

Mode of diagnosis of metastatic breast cancer recurrence and survival: a retrospective study

Randomized studies failed to show a survival benefit for screening asymptomatic breast cancer (BC) survivors for metastases, however, their relevance to the era of modern systemic therapies is unknown. Socioeconomic status (SES) may confound the association between mode of diagno...

Clinical liability cases reveal a coupling between legal defensibility and medical procedure escalation in large language models

Large language models (LLMs) are increasingly used for clinical decision support, yet their resource utilization implications remain largely unstudied. We introduce CLAD (Clinical Legal Accountability Dataset), evaluating fifteen LLMs on 198 US medical malpractice cases to assess...

Beyond the battlefield: Interpersonal predictors of women's mental health during extended partner deployment

Abstract Objective The goal was to identify predictors of psychological distress and growth in reservists' wives. Background The prolonged Swords of Iron War has placed an unprecedented burden on Israeli reservists' partners. This study explored their psychological, relational, a...