Ramathibodi Hospital

An international multicenter analysis of the outcome of pediatric first variceal hemorrhage

Background & Aims: Management of portal hypertension in children including primary prophylaxis of variceal bleeding is controversial due to limited understanding of mortality risk after first variceal hemorrhage (1VH). This international multicenter study was designed to advance...

Association between medical school admission pathways and documented extracurricular research participation: a sequential explanatory mixed-methods study

Abstract Background Medical schools that use multiple admission pathways may admit students with varying research-related experiences and opportunities. We examined the association between admission pathway and documented extracurricular research participation during medical trai...

Immunogenicity and safety of high-dose versus double-dose quadrivalent inactivated influenza vaccine in adult kidney transplant recipients: a randomized controlled trial (2023)

Background Solid organ transplant (SOT) recipients are at increased risk of influenza-related complications and often exhibit suboptimal vaccine responses. While both high-dose (HD) and double-dose (DD) quadrivalent inactivated influenza vaccines (QIIV) aim to enhance immunogenic...

Electrochemical Dual-Sensing Platform for HLA-B*13:01 Detection to Prevent Severe Cutaneous Adverse Reactions (SCARs) Induced by Dapsone and Cotrimoxazole

Abstract The HLA-B*13:01 allele is a critical biomarker for dapsone- and cotrimoxazole-induced severe cutaneous adverse reactions (SCARs). Overcoming the limitations of centralized laboratory screening, we developed a portable electrochemical dual-sensing platform (EDP) for the s...

Tapetal-like reflex in RPGR-associated retinal dystrophies: two cases with distinct phenotypes

Retinitis pigmentosa GTPase regulator (RPGR) mutations are associated with X-linked inherited retinal diseases (IRDs), with variable phenotypes including retinitis pigmentosa (RP), cone-rod dystrophy (CRD), and cone dystrophy (CD). Tapetal-like reflex (TLR) is commonly observed i...

Mitral Valve Lithotripsy With SmartCrack Balloon for Severe Calcified Mitral Stenosis: First‐in‐Human Experience

Background Mitral stenosis due to mitral annular calcification and calcific rheumatic heart disease (CRHD) remains challenging to treat. This first‐in‐human study evaluated the safety and feasibility of the dedicated SmartCrack lithotripsy balloon in patients with severe mitral s...

Immunogenicity and safety of high-dose versus standard-dose quadrivalent inactivated influenza vaccine in patients living with HIV: a randomized controlled trial

Influenza remains a major cause of morbidity in people living with HIV (PLWH), and despite recommendations for annual vaccination with the standard-dose (SD) quadrivalent inactivated influenza vaccine (IIV4), immune responses are often suboptimal in this population. To address th...

Immune Checkpoint Inhibitors in Resectable and Locoregionally Advanced HNSCC: Past Lessons, Present Evidence, and Future Directions

Abstract The integration of ICIs has reshaped therapeutic strategies in head and neck squamous cell carcinoma (HNSCC). ICIs are established in recurrent/metastatic (R/M) HNSCC and have been extensively evaluated in resectable and locoregionally advanced (LA) disease, without succ...

Case Report: Two-year consequences of barium sulfate aspiration

Aspiration of barium sulfate is a rare but recognized complication of upper gastrointestinal contrast studies. While the acute clinical manifestations have been widely reported, information on the long-term radiographic course and systemic absorption of retained pulmonary barium...

Diagnostic yield and impact of internal transcribed spacer sequencing from clinical specimens on antifungal management in patients with suspected fungal infection

Internal transcribed spacer (ITS) sequencing has been increasingly used for the diagnosis of fungal infection. However, data on its real-world clinical utility are limited. We retrospectively evaluated the diagnostic yield from direct clinical specimens using the final diagnosis...

Transition of children with chronic gastrointestinal and liver disease to adult care: A multicentre Asian survey of paediatric gastroenterologists

OBJECTIVES: The rising incidence of chronic gastrointestinal conditions and better survival of children with life-limiting diseases have resulted in the need for continuity of care into adulthood. This study aimed to detail transition practices in paediatric gastroenterology and...

SpineXR-VQA: A Clinically-Validated Visual Question Answering Dataset for Spine X-Rays

Recent progress in Medical Visual Question Answering (VQA) has significantly aided clinical decision-making across various domains such as pneumonia, oncology, and neurology. However, spinal and musculoskeletal ailments remain critically underexplored. The development of reliable...

Medication errors in home care settings: a 13-year retrospective cohort study in the Ramathibodi Poison Center

INTRODUCTION: Medication errors are a leading cause of preventable harm worldwide, yet evidence has predominantly focused on healthcare settings, with limited data from home care, particularly in Southeast Asia. METHODS: We conducted a retrospective cohort study using 2011-2023 d...

Shared and Distinct T-Cell Receptor Characteristics of CD4+ and CD8+ Drug-Specific T-Cells In Vitro Generated from Healthy Donors and Hypersensitive Patients

Abstract The initiation of T-cell-mediated drug hypersensitivity reaction requires the formation of a human leukocyte antigen (HLA)-peptide-drug-T-cell receptor (TCR) complex. While specific interactions between HLA molecules and drug antigens are well-defined, the characteristic...

Laboratory Concordance and Prognostic Impact of 10‐Color Flow Cytometry and Next‐Generation Sequencing‐Based Immunoglobulin Gene Assay for Measurable Residual Disease Monitoring in Adult B‐Cell Acute Lymphoblastic Leukemia: A Multicenter Study From Thai Acute Leukemia Working Group ( TALWG )

ABSTRACT Aims Measurable residual disease (MRD) is a key prognostic marker for patient survival. This study evaluated concordance between 10‐color flow cytometry and next‐generation sequencing (NGS)–based immunoglobulin heavy chain (IGH) gene assays for MRD detection and to asses...

Modified nasopharyngeal airway device facilitates nasal fiberoptic intubation for trainee anesthesiologists: a randomized clinical study

Fiberoptic nasotracheal intubation is an essential skill for anesthesiologists. Trainee anesthesiologists often face challenges due to the complex anatomy of the nasopharynx and the risk of upper airway collapse after anesthesia administration, which can lead to confusion and dif...

Clinical Meaningfulness and Improvement Thresholds of Myositis Core Set Measures: Association with Patient-Reported Outcomes

Objective The study aimed to evaluate the clinical meaningfulness and improvement thresholds of the myositis core set measures (CSMs) of disease activity in idiopathic inflammatory myopathies (IIM), emphasizing associations with patient-reported outcome measures (PROMs). Methods...

Patterns of the gut microbiota and metabolome as potential biomarkers associated with influenza vaccine immunogenicity in systemic lupus erythematosus: a cross-sectional observational pilot study

Immunogenicity to influenza vaccination is often impaired in systemic lupus erythematosus (SLE). The role of the gut microbiota and its metabolic output in modulating this response remains underexplored. This study is the first to explore gut microbiota patterns and metabolites i...

Landscape of industry-sponsored oncology trials across the Thai Society of Clinical Oncology (TSCO): a 12-year multicenter analysis

Cancer remains a major global health challenge and is a leading cause of morbidity and mortality in Thailand. Industry-sponsored oncology trials (ISOTs) provide critical access to innovative therapies, including targeted agents, immunotherapies (IO), and antibody–drug conjugates...

Incorporating Naive Bayes classification to address subpopulation structure in familial DNA search

Familial DNA search evaluates the genetic relatedness of two individuals by comparing the likelihood of their observed DNA profiles under two competing hypotheses-the null hypothesis that the individuals are unrelated and the alternative hypothesis that they are related-most comm...