Quzhou City People's Hospital

MRI‑based radiomics nomogram for distinguishing malignant tumor from benign ones in the orbit: a two‑center study

Accurate differentiation between malignant and benign orbital tumors is essential for clinical decision-making and treatment planning. MRI-based radiomics, which extracts high-dimensional quantitative features from medical images, has emerged as a promising noninvasive approach f...

Chlorogenic Acid Derivative B11 Inhibits Glioma Proliferation by Targeting MST4 to Regulate Oxidative Stress

ABSTRACT This study focuses on the mechanism of action of chlorogenic acid derivative B11 on glioma. Although chlorogenic acid exhibits certain anti‐tumor activity, it has limitations such as low bioavailability, broad action targets, and insufficient specificity, which restrict...

Development of ferroptosis-related prognostic signature for lung adenocarcinoma and association of fibroblast-enriched RGS4 with favorable prognosis

Lung adenocarcinoma (LUAD) is characterized by high incidence and low survival rate. The molecular network of ferroptosis in lung adenocarcinoma requires further investigation, and this study aims to develop a ferroptosis-related prognostic model and identify the potential biomar...

Multi-Scale MRI, Radiology Reports, and Blood Biomarker–Guided Multimodal Deep Learning for Predicting Postoperative Recurrence in Cervical Cancer: A Multicenter Study

Objectives: Cervical cancer (CC) remains a leading cause of cancer-related morbidity and mortality among women worldwide, with postoperative recurrence posing a major challenge to long-term survival. Multimodal data integration, including imaging, textual, and clinical informatio...

Development and validation of MRI-based radiomics models for predicting recurrence in patients with spine and pelvis chordomas

Spine and pelvis chordoma (SPC) is a rare and aggressive mesenchymal tumor with poor long-term recurrence-free survival rates. Accurate preoperative prediction of recurrence remains a significant clinical challenge, and reliable prognostic methods are lacking. To develop and vali...

Prediction of low oocyte retrieval in young women undergoing IVF/ICSI: a multicenter external validation study

Abstract Objective To externally validate a previously developed pretreatment prediction nomogram for identifying young women at risk of low oocyte retrieval (LOR). Methods This multicenter retrospective study included 14,702 women aged ≤ 35 years undergoing their first in vitro...

Clinical application of systematic prostate biopsy combined with contrast-enhanced ultrasound guided targeted biopsy in patients with PSA gray zone

Abstract Objective To investigate the clinical value of combining systematic prostate biopsy with contrast-enhanced ultrasound (CEUS)-guided targeted biopsy in patients with serum prostate-specific antigen (PSA) levels in the gray zone. Methods A total of 167 patients in the PSA...

Preoperative C-Reactive Protein–Albumin–Lymphocyte Index and Related Clinical Factors Associated With Postoperative Complications Following Cholecystectomy in Acute Cholecystitis: A Retrospective Study

AIM: Laparoscopic cholecystectomy (LC) is the primary treatment for acute cholecystitis (AC), although various postoperative complications may still occur. Inflammatory composite indices have gained increasing attention in surgical risk assessment; among them, the C-reactive prot...

Heat stress enhances gut microbial arginine catabolism to amplify MyD88-dependent inflammatory responses

As global temperatures continue to rise, heat stress (HS) has emerged as a major health threat of growing concern. HS triggers systemic inflammation and multi-organ damage, but so far its molecular mechanisms remain unclear. In this study, we explored the potential mechanism by w...

A large-scale multi-center analysis reveals that HNRNPA2B1 variants increase neuroblastoma risk in Chinese children

Neuroblastoma has significant clinical heterogeneity, more precise genetic biomarkers are needed for early risk stratification. Although m 6 A modification has been reported to affect tumor development, the epidemiological impact of HNRNPA2B1 polymorphisms on neuroblastoma suscep...

Serum clusterin, neurofilament light chain, and LDL-C cholesterol for risk stratification of cognitive impairment in parkinson’s disease

Serum biomarkers, due to their advantages of easy accessibility and repeatability, show significant potential for early identification and stratification of cognitive impairment in Parkinson's disease (PD). This study aimed to systematically evaluate the expression differences of...

A multimodal Vision-Mamba model based on non-contrast CT hematoma and shell features predicts early hematoma expansion in hypertensive intracerebral hemorrhage: a multicenter study

To develop and evaluate a multimodal Vision-Mamba deep learning (DL) model integrating clinical data, noncontrast computed tomography (NCCT) hematoma features, and shell features to predict early hematoma expansion (EHE) in hypertensive intracerebral hemorrhage (HICH). In this mu...

Insulin resistance as a potential mediator between central obesity and diabetic kidney disease risk in type 2 diabetes

Abstract Obesity is a key risk factor for diabetic kidney disease (DKD). However, BMI fails to capture body fat distribution. We hypothesized that central obesity, rather than generalized obesity, is associated with DKD risk in patients with type 2 diabetes mellitus (T2DM), and t...

Latent profile analysis and associated factors of injection-related fear in school-aged children: a cross-sectional investigation

Injection-related fear in school-aged pediatric patients may influence their cooperation with medical procedures and psychological wellbeing. However, few studies have characterized distinct latent profiles of injection-related fear in this pediatric population. To further clarif...