Queen's Medical Centre

Both CD8+ and CD4+ T regulatory cells are associated with poor survival in colorectal cancer

Abstract Previous studies in colorectal cancer have linked high levels of FoxP3 + regulatory T-cells (Treg) (CRC) to favourable prognosis. However, this contradicts the well-established immunosuppressive function of Treg. We resolved this conundrum using multiplex immunohistochem...

Chloride-permeable channels in white adipocytes: their role in adipogenesis and membrane potential

Abstract Ion fluxes, regulated by membrane potential (Vm), are vital to white fat adipocyte (WFA) function and adipogenesis. These processes present a novel target to intervene in obesity. To explore this possibility we applied transcriptomics, immunohistochemistry, electrophysio...

Non-medical surgical delay increases one-year mortality following hip fracture

Aims: This study aimed to assess the association between surgical delay due to non-medical reasons and one-year mortality in patients with hip fracture, and to explore whether a dose-response relationship exists between increasing time to surgery and mortality risk. Methods: A re...