Queen Elizabeth II Health Sciences Centre

To Walk or Not? A Prospective, Randomised Controlled Trial to Evaluate the Effect of Weightbearing on Patient Outcomes Following First Metatarsophalangeal Joint Fusion

Background: First metatarsophalangeal (MTP) joint arthrodesis is the gold standard surgical treatment of hallux rigidus and severe hallux valgus with osteoarthritis after failed nonoperative management. Despite its common use, postoperative weightbearing protocols vary considerab...

Technical replicates and multiple sequencing approaches reveal weak and inconsistent microbiome signals in lung tumour and blood samples from patients with lung cancer

Abstract Background Unique bacterial profiles have been described in tumours, blood, and other low biomass samples. However, recent controversy has highlighted the challenges of utilising these microbiomes for cancer diagnosis and treatment. This work aims to characterise current...