Quadram Institute

Shared household environment structures the gut microbiota in a large family cohort with central areolar choroidal dystrophy

Central areolar choroidal dystrophy (CACD) is a rare monogenic hereditary retinal dystrophy characterised by progressive retinal pigment epithelium and choriocapillaris atrophy, photoreceptor loss, oxidative stress, and chronic inflammation. Emerging evidence suggests that the gu...

Systemically delivered Bacteroides thetaiotaomicron -derived bacterial extracellular vesicles inhibit primary and metastatic melanoma growth

ABSTRACT The gut microbiome can contribute to anti-tumor immunity and cancer therapy responses, but translating live microbe-based interventions remains challenging due to safety, controllability, and delivery constraints. Bacterial extracellular vesicles (BEVs) are an attractive...

Structural genome variation drives adaptation of the xylose-fermenting yeast Scheffersomyces stipitis to lignocellulosic hydrolysates

Abstract Second-generation (2G) bioethanol from lignocellulosic feedstocks is a sustainable alternative to fossil fuels. However, its production is constrained by the poor performance of industrial microbes in hydrolysates that are generated during biomass pretreatment. Scheffers...

Distinct gut viral communities across life stages in dairy cattle

Abstract Background Ruminant gut microbial communities influence host health, productivity, and methane emissions, yet viral communities across life stages remain uncharacterized. Whilst bacteriophages shape microbial communities in many ecosystems, their role across dairy cattle...

Whole genome comparative analysis shows limited Escherichia coli co-occurrence within co-habiting humans and dogs

Abstract Background Dogs are one of the most popular companion animals in the UK, with an estimated 13.5 million within UK households. Within these households, human-animal physical interactions may lead to inter-species bacterial sharing, including Escherichia coli . E. coli is...