Qom University of Medical Science and Health Services

Design, synthesis, and biological evaluation of novel 4,5-diaryl-1,2,3-thiadiazole derivatives: anticancer activity and molecular docking studies

Malignancies remain a major global health challenge. Microtubule-targeting agents (MTAs) have emerged as a significant therapeutic class, effectively suppressing cancer cell proliferation by interfering with the normal dynamics of microtubules. Combretastatin, particularly combre...

In vitro osteogenic potential of melatonin-loaded magnesium-containing mesoporous bioactive glass nanoparticles

A multifunctional nanoscale system was engineered by incorporating melatonin into magnesium-containing mesoporous bioactive glass (Mg-MBG) through adsorption within its porous network. The resulting formulation was designed to enable site-specific melatonin delivery while support...

From knowledge to action: health literacy and health-promoting behaviors in parents of autistic children, a cross-sectional study in Iran

Children with Autism Spectrum Disorder (ASD) depend on their parents for their health and well-being, especially in Iran where formal services for children with ASD are limited and families play a central role in daily care. The most effective diagnostic and therapeutic intervent...

Associations of major depressive disorder, generalized anxiety disorder, obsessive-compulsive disorder, and aggression with subclinical variations in kidney function biomarkers among young adults: A cross-sectional study from the rafsanjan youth cohort study

Psychiatric disorders emerging during adolescence and young adulthood may be associated with variations in physiological systems beyond the brain, including kidney function biomarkers. However, most previous research examining psychiatric disorders and kidney-related outcomes has...

Barriers and facilitators of adolescents’ adherence to iron and vitamin D supplementation: a qualitative study

Abstract Background Iron and vitamin D deficiencies remain important public health concerns among adolescents. Despite the implementation of school-based supplementation programs in Iran, adherence to supplement use remains suboptimal. This study explored school health profession...

The Gut-Brain Axis in Neurodegeneration: Mechanistic Links Between Dysbiosis and Neuropathology.

Background & Objective: The gut-brain axis is essentially a two-way communication system that physically connects the brain and the intestinal tract. The connection is mediated through a series of pathways, including neural, endocrine, and immune pathways. Gut dysbiosis, which is...

Ecological analysis of Cutaneous leishmaniasis incidence and climatic variability in Kashan and Aran - Bidgol, Iran (2014–2024)

Cutaneous leishmaniasis (CL) is a major neglected tropical disease whose transmission is strongly influenced by climatic and environmental conditions. This study investigated the temporal associations between climatic variables and CL incidence in Kashan and Aran and Bidgol count...

The molecular mechanisms of platelets in tumor invasion and metastasis: a controversial role

Platelets, traditionally recognized for their role in hemostasis, are now understood to actively contribute to tumor progression, angiogenesis, and metastasis. Through dynamic bidirectional interactions with cancer cells, platelets undergo measurable alterations in count, mean pl...

Comparison of treatment delays and in-hospital outcomes between self-transported and EMS-transported patients with ST-segment elevation myocardial infarction undergoing PCI

The effectiveness of reperfusion therapy in patients with myocardial infarction (MI) depends largely on timely treatment. This study aimed to compare treatment delays and in-hospital outcomes between self-transported and EMS-transported patients with STEMI. This retrospective obs...