Qatar Airways (Qatar)

Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation

Abstract Background Bioactive peptides (BAPs), derived from both natural and synthetic sources, are increasingly recognized as multifunctional agents with potential roles in the management of cancer and inflammatory conditions, in addition to their well‐established antimicrobial...

Sleep quality in infants with atopic dermatitis: impact of lesion location and disease severity in a retrospective cross-sectional study

Atopic dermatitis (AD) is a common inflammatory skin disorder in infants and is frequently associated with sleep disturbances. Although the relationship between disease severity and sleep quality is well established, the effect of lesion localization on sleep has not been thoroug...

SLFN11 enhances cisplatin sensitivity in pediatric cancer via activation of stress-response and suppression of survival pathways

Abstract Background Paediatric cancers pose treatment challenges due to biological heterogeneity and variable chemotherapy responses. SLFN11, a DNA/RNA helicase-like protein known to sensitise adult tumours to DNA-damaging agents, remains underexplored in paediatric malignancies....

Human iPSC-based modeling reveals coding and non-coding transcriptomic alterations associated with RFX3 deficiency in pancreatic islets

Abstract Background RFX3 is a transcription factor (TF) critical for pancreatic endocrine development. Its loss impairs β-cell differentiation, promotes enterochromaffin cell (EC) generation, and induces apoptosis. However, the role of non-coding RNAs in mediating these effects r...