Putian University

Apigenin Alleviates Ligamentum Flavum Ossification by Dual-Targeting CA9 and CDK6 and Modulating Calcium/PI3K–Akt Signaling

While apigenin shows therapeutic potential for bone-related disorders like osteoporosis and osteoarthritis, its mechanisms in regulating ligamentum flavum ossification (OLF) are unclear. An integrated computational strategy combining network pharmacology, machine learning, and mo...

Marker chromosomes in 15 individuals: cytogenetic delineation and molecular findings from SNP array analysis in a subset of cases

Abstract Objective Marker chromosomes (MCs) are structurally abnormal chromosomes that can be detected by standard cytogenetic banding techniques but their precise structure and origin cannot be fully determined by these methods alone. These abnormal chromosomes can be present as...

In Situ CdS-MediatedOrganic PhotoelectrochemicalTransistor Sensor for Highly Sensitive H2S Detection

Abstract Hydrogen sulfide (H2S) serves as an important gasotransmitter implicated in vascular regulation, neuroprotection, and redox homeostasis, and its aberrant fluctuation is closely associated with diverse pathological disorders. Consequently, the development of sensitive and...

Calciphylaxis in chronic kidney disease: a systematic review of pathomechanisms and risk factors for calcific uremic arteriolopathy

Calcific uremic arteriolopathy (CUA) is a rare, severe condition affecting patients with chronic kidney disease (CKD). The etiology of CUA is unclear. Here, we aimed to identify factors associated with its development. We reviewed the existing evidence on its pathomechanisms and...

Novel CTLA4 Haploinsufficiency with Pure Red Cell Aplasia as the Core Manifestation: Insights from a Sibling Pair with Divergent Tumorigenic Outcomes

Cytotoxic T‑lymphocyte antigen‑4 (CTLA4) is a key immune checkpoint molecule, and its haploinsufficiency can lead to a highly heterogeneous immune dysregulation syndrome; however, its association with pure red cell aplasia (PRCA) remains to be systematically characterized. Here w...

Dietary Inflammatory Index, Physical Activity, and Inflammation-Related Health Outcomes: A Narrative Review and Inflammatory Resilience Framework

How physical activity may modify the health consequences of a pro-inflammatory diet remains an important but unresolved question. This hypothesis-generating narrative review examines this question by integrating evidence on dietary inflammatory potential, physical activity, physi...

Integrative network toxicology and computational modeling uncover the mechanism of aflatoxin B1-induced nephrotoxicity

Aflatoxin B1 (AFB1) is a highly toxic mycotoxin that causes severe renal injury, yet the molecular basis of its nephrotoxicity remains poorly defined. Here, we integrated multi-omics data with computational modeling to elucidate the mechanisms of AFB1-induced kidney damage. Three...