Putian University

Active Visual Perception: Opportunities and Challenges

Active visual perception enables an intelligent system to improve perception by controlling how visual evidence is acquired. However, differences in how studies define active perception and evaluate its benefits make approaches difficult to compare across tasks. This review first...

Pulmonary CT classification based on CNN and Grad-CAM explainability using VGG16 and MobileNetV2

Abstract Objectives This study compared the classification performance of VGG16 and MobileNetV2 models for normal-versus-lung-cancer-positive pulmonary CT image classification, with Grad-CAM used for post-hoc visual explainability. Methods A hospital-provided dataset of 550 non-c...

Clinical characteristics, antimicrobial susceptibility, and diagnostic performance of the LRINEC score for necrotizing fasciitis in Vibrio vulnificus infection: a 19-case retrospective study in Putian, China

Vibrio vulnificus infection is a life-threatening marine-associated disease that can progress rapidly. Regional differences have been reported in its clinical manifestations and antimicrobial resistance patterns. However, baseline epidemiological and microbiological data on this...

Trichinella spiralis galectin disrupts gut epithelial integrity and mediates larval invasion via acting MUC13- ROCK2/MAPK pathway

Background Gut epithelium serves as a critical barrier against Trichinella spiralis larval invasion, Parasite-derived galectins are involved in host–parasite interactions, including invasion and immune modulation. This study investigated the role of T. spiralis galectin (Tsgal) i...

ETV4 promotes lipid accumulation and oxidative stress in metabolic dysfunction-associated fatty liver disease by transcriptionally activating TYMS

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic liver disorder, with non-alcoholic steatohepatitis (NASH) as its progressive stage. This study aimed to identify diagnostic biomarkers and investigate the mechanism by which ETS variant transcription factor...

Intraluminal thrombus distribution pattern is associated with abdominal aortic aneurysm rupture at presentation: a single-centre retrospective study

Intraluminal thrombus (ILT) is present in the majority of abdominal aortic aneurysms (AAA), yet its role in rupture remains incompletely defined. This study examined whether the circumferential distribution pattern of ILT—classified as circumferential, eccentric, or absent/minima...

Efficient Similarity Detection for Delta Compression

Delta compression is a promising technique for reducing the storage footprint of similar data. As the first step in delta compression, similarity detection has a significant impact on both the delta compression ratio (DCR) and the compression throughput. Unfortunately, existing a...

Lactylation of OVOL2 impairs its tumor-suppressive activity to promote hepatocellular carcinoma growth

Lactylation, a metabolism-associated post-translational modification derived from lactate accumulation, has emerged as an important regulator linking metabolic reprogramming to cancer progression. Increasing evidence suggests that lactylation participates in tumor development thr...

Anastomotic distance from the right gastroepiploic artery terminus is associated with anastomotic leakage after neoadjuvant immunochemotherapy and minimally invasive esophagectomy: a retrospective cohort study

Abstract Background Minimally invasive esophagectomy (MIE) after neoadjuvant immunochemotherapy is standard for locally advanced esophageal cancer, but anastomotic leakage (AL) remains common and severe. Perfusion of the gastric conduit via the right gastroepiploic artery (RGEA)...

Type I and II pili mediate transcytosis of Streptococcus pneumoniae across blood-brain barrier cells in the pathogenesis of pneumococcal meningitis

Streptococcus pneumoniae , a common pathogen to cause pneumonia and otitis media, is also the most important causative agent of bacterial meningitis in humans. Previous studies have shown that S. pneumoniae strains can be pilus-negative, type I pilus- and/or type II pilus-positiv...

Apigenin Alleviates Ligamentum Flavum Ossification by Dual-Targeting CA9 and CDK6 and Modulating Calcium/PI3K–Akt Signaling

While apigenin shows therapeutic potential for bone-related disorders like osteoporosis and osteoarthritis, its mechanisms in regulating ligamentum flavum ossification (OLF) are unclear. An integrated computational strategy combining network pharmacology, machine learning, and mo...

Marker chromosomes in 15 individuals: cytogenetic delineation and molecular findings from SNP array analysis in a subset of cases

Abstract Objective Marker chromosomes (MCs) are structurally abnormal chromosomes that can be detected by standard cytogenetic banding techniques but their precise structure and origin cannot be fully determined by these methods alone. These abnormal chromosomes can be present as...

In Situ CdS-MediatedOrganic PhotoelectrochemicalTransistor Sensor for Highly Sensitive H2S Detection

Abstract Hydrogen sulfide (H2S) serves as an important gasotransmitter implicated in vascular regulation, neuroprotection, and redox homeostasis, and its aberrant fluctuation is closely associated with diverse pathological disorders. Consequently, the development of sensitive and...

Calciphylaxis in chronic kidney disease: a systematic review of pathomechanisms and risk factors for calcific uremic arteriolopathy

Calcific uremic arteriolopathy (CUA) is a rare, severe condition affecting patients with chronic kidney disease (CKD). The etiology of CUA is unclear. Here, we aimed to identify factors associated with its development. We reviewed the existing evidence on its pathomechanisms and...

Novel CTLA4 Haploinsufficiency with Pure Red Cell Aplasia as the Core Manifestation: Insights from a Sibling Pair with Divergent Tumorigenic Outcomes

Cytotoxic T‑lymphocyte antigen‑4 (CTLA4) is a key immune checkpoint molecule, and its haploinsufficiency can lead to a highly heterogeneous immune dysregulation syndrome; however, its association with pure red cell aplasia (PRCA) remains to be systematically characterized. Here w...

Integrative network toxicology and computational modeling uncover the mechanism of aflatoxin B1-induced nephrotoxicity

Aflatoxin B1 (AFB1) is a highly toxic mycotoxin that causes severe renal injury, yet the molecular basis of its nephrotoxicity remains poorly defined. Here, we integrated multi-omics data with computational modeling to elucidate the mechanisms of AFB1-induced kidney damage. Three...

Dietary Inflammatory Index, Physical Activity, and Inflammation-Related Health Outcomes: A Narrative Review and Inflammatory Resilience Framework

How physical activity may modify the health consequences of a pro-inflammatory diet remains an important but unresolved question. This hypothesis-generating narrative review examines this question by integrating evidence on dietary inflammatory potential, physical activity, physi...