Pusan National University Yangsan Hospital

Unintended consequences of vaginal misoprostol use in a patient with hydatidiform mole

Rationale: Hydatidiform mole (HM) is usually managed by suction curettage, while misoprostol is not recommended as a method of medical evacuation for molar pregnancy because of concerns regarding incomplete evacuation and postmolar gestational trophoblastic neoplasia. The use of...

Cost-competitive design of sustainable urea production: Synergizing solid oxide electrolysis and oxy-fuel combustion-based carbon capture

Urea is a vital nitrogen fertilizer for global food security; however, its production remains carbon-intensive owing to heavy reliance on fossil fuel–based H 2 . To reduce the carbon emissions of the urea production process, capturing CO 2 from the flue gas has emerged as a promi...

Multimodal analgesic approach using poloxamer 407-based ropivacaine hydrogel and scheduled intravenous acetaminophen following totally laparoscopic distal gastrectomy: a retrospective cohort study

Abstract Background For laparoscopic gastrectomy, patient-controlled intravenous analgesia (PCIA) alone is often insufficient and may contribute to excessive opioid consumption. Current Enhanced Recovery After Surgery (ERAS) guidelines recommend multimodal analgesia (MMA). This s...

Comparative study on the clinical effectiveness of low-concentration cyclosporine eye drops in patients with dry eye disease

Purpose This study aimed to evaluate the efficacy and safety of low-concentration, nanoparticle-based cyclosporine eye drops (SCAI-001 0.01% and SCAI-001 0.02%) compared to those of the conventional Restasis ® (cyclosporine 0.05%) emulsion for dry eye disease (DED). Methods In th...

Seroprevalence of Toxoplasma gondii among animal-associated workers and companion animals in South Korea

Abstract Toxoplasma gondii is a widely distributed zoonotic parasite at the human–animal interface. However, studies simultaneously evaluating animal-associated workers and companion animals remain limited in South Korea. This multi-regional cross-sectional study aimed to estimat...

The effects of different vitamin mixtures on growth performance, rumen fermentation parameters, serum metabolites, and heat stress biomarkers in Hanwoo heifers under high temperature-humidity condition

in Hanwoo heifers under high temperature-humidity condition

Temporal changes in ocular-surface bacterial contamination during cataract surgery and vitrectomy: effect of povidone–iodine

Postoperative endophthalmitis remains a serious complication of intraocular surgery, and reducing ocular-surface bacterial contamination is an important preventive strategy. We retrospectively evaluated temporal changes in ocular-surface/canthal irrigation-fluid culture positivit...

Association of Serum 1,25-Dihydroxyvitamin D Levels with Erythropoietin Resistance Index-Based Relative Erythropoiesis-Stimulating Agent Hyporesponsiveness in Pre-Dialysis Chronic Kidney Disease

Erythropoiesis-stimulating agent (ESA) hyporesponsiveness is a major challenge in the management of anemia in chronic kidney disease (CKD). This study evaluated the association between serum 1,25-dihydroxyvitamin D [1,25(OH)2D] levels and ESA responsiveness in patients with pre-d...

Discordant Antitumor Efficacy with Compromised Survival in High-Risk Unresectable Hepatocellular Carcinoma

Background/Objectives: Real-world data in high-risk patients remain limited; this study evaluated survival, safety, and prognostic factors in this patient group. Methods: This multicenter study retrospectively reviewed 783 patients who received Ate/Bev from 2022–2024 across South...

Lactococcus Lactis Subsp. Lactis CAB701 Reduces Body fat mass in Adults with Overweight or Obesity: A Randomized, Double-Blind, Placebo-Controlled Trial

Abstract Probiotic-based strategies have gained increasing attention as potential interventions for obesity and metabolic disorders. Lactococcus lactis subsp. lactis CAB701 (CAB701), a cabbage-derived probiotic strain, has demonstrated anti-adipogenic activity in preclinical stud...

Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome

Background: Survivors of critical illness commonly experience persistent physical, cognitive, and psychological impairments, collectively known as post–intensive care syndrome. Although intensive care unit (ICU) rehabilitation is now recognized as an important part of recovery af...

Unmasking delayed recovery in severe diabetic ketoacidosis: clinical and biochemical clues from early resuscitation

Purpose: This study aimed to explore how the rate of acidosis correction relates to initial clinical status, treatment needs, and short-term outcomes in severe diabetic ketoacidosis (DKA).Methods: This retrospective study reviewed records of patients aged 1–18 with severe DKA adm...

Nurse-led preprocedural Valsalva maneuver training with a maximal expiratory pressure device during transesophageal echocardiography in South Korea: a quasi-experimental study

Purpose: This study examined the effects of preprocedural Valsalva maneuver (VM) training using a maximal expiratory pressure (MEP) device on VM performance and patient discomfort during transesophageal echocardiography (TEE).Methods: This study used a time-lagged, posttest-only,...

Association of the COVID-19 lockdown and Generalized Anxiety Disorder-7 (GAD-7) in Korean adolescents

Coronavirus disease 2019 (COVID-19) is a worldwide pandemic that causes anxiety. Research on possible risk factors for anxiety during the COVID-19 pandemic is scarce. In this study, we examined 54,890 participants’ web-based self-reported data from the Korea Youth Risk Behavior W...

Comparative Analysis of Cotton- and Flocked-Swab-Based Culture Methods in Bacterial Keratitis

Purpose: To compare the diagnostic performance of flocked-swab and cotton-swab culture methods in patients with bacterial keratitis.Methods: Twentytwo patients diagnosed with bacterial keratitis between May 2024 and August 2025 were included. Corneal specimens were collected usin...

Clinical Characteristics and Outcomes of Pediatric Patients With Long QT Syndrome: A Korean Multicenter Cohort Study

This multicenter nationwide cohort study comprehensively analyzed the clinical features, genetic architecture, and outcomes of Korean pediatric patients with long QT syndrome (LQTS).Prolonged QT intervals, fetal arrhythmia, and LQT2/3 genotypes compared to LQT1 were independent r...

Impact of intertrochanteric bone mineral density on the accuracy of preoperative templating in cementless total hip arthroplasty: a retrospective cohort study of 510 hips

Abstract Background Preoperative templating accuracy in cementless total hip arthroplasty (THA) may be influenced by patient-specific and radiographic factors, yet bone quality has rarely been considered. We hypothesized that bone mineral density (BMD), and particularly intertroc...

Integrative Genomic Analysis Reveals Molecular and Clinical Disparities between Bladder and Upper Tract Urothelial Carcinoma in K-MASTER Program

Purpose: The clinical outcome of urothelial carcinoma presents significant variability, reflecting its molecular composition, epidemiologic attributes, and primary site of origin. Despite histological similarities, upper tract urothelial carcinoma (UTUC) and bladder urothelial ca...

Accuracy of Pedicle Screw Placement at the Cervicothoracic Junction (C7–T2) : A Comparative Study of O-arm Navigation versus C-arm Fluoroscopy

Objective: To compare pedicle screw accuracy at the cervicothoracic junction (CTJ; C7-T2) between O-arm navigation and C-arm fluoroscopy and identify level-specific malposition mechanisms through quantitative trajectory analysis. Methods: We retrospectively reviewed 187 screws in...