Pusan National University Hospital

Changes in General Anesthesia Utilization Disparity among Patients with Autism Spectrum Disorder Before and After Health Insurance Coverage Expansion: A Retrospective Analysis of a Single Regional Specialized Dental Center, 2021-2025

Background: Patients in Korea with autism spectrum disorder (ASD) rely heavily on general anesthesia (GA) during dental treatments at specialized dental centers.In February 2022, the expanded National Health Insurance (NHI) coverage reduced out-ofpocket expenses for patients unde...

Biospecimen Integrity and Short-Term Analyte Stability after Pneumatic Tube Transport: Validation and Pressure Optimization of the TEMPUS 600 System in a Tertiary Care Hospital

Background: Pneumatic tube systems (PTS) reduce preanalytical delay but impose mechanical stress that can hemolyse specimens. We validated the TEMPUS 600 PTS at a tertiary hospital and sought an operating pressure that minimized transport-related hemolysis. Methods: Specimens wer...

Unintended consequences of vaginal misoprostol use in a patient with hydatidiform mole

Rationale: Hydatidiform mole (HM) is usually managed by suction curettage, while misoprostol is not recommended as a method of medical evacuation for molar pregnancy because of concerns regarding incomplete evacuation and postmolar gestational trophoblastic neoplasia. The use of...

Current Guidelines for the Laboratory Detection and Interpretation of Lupus Anticoagulant

역 혈전성 질환이다.APS 진단에 필요한 검사 기준으로는 루푸스 항응고인자(lupus anticoagulant, LAC), 항카디오리핀 항체(anti-cardiolipin antibody, aCL), 항β2-당단백질 I 항체(anti-β2-glycoprotein I antibody, aβ2GPI)가 있으며, 이 중 LAC는 혈전 위험도와의 연관 성이 가장 강력하다[1, 2]."...

Comparative study on the clinical effectiveness of low-concentration cyclosporine eye drops in patients with dry eye disease

Purpose This study aimed to evaluate the efficacy and safety of low-concentration, nanoparticle-based cyclosporine eye drops (SCAI-001 0.01% and SCAI-001 0.02%) compared to those of the conventional Restasis ® (cyclosporine 0.05%) emulsion for dry eye disease (DED). Methods In th...

Survival impact of repeated endobiliary radiofrequency ablation in patients undergoing durvalumab plus gemcitabine and cisplatin for extrahepatic cholangiocarcinoma (BRAVE trial): study protocol for an international multicenter randomized controlled trial

Extrahepatic cholangiocarcinoma (eCCA) often presents with unresectable disease and obstructive jaundice. Systemic therapy with gemcitabine–cisplatin plus durvalumab (GCD) is an international standard; however, the median overall survival (OS) remains about 1 year. Endobiliary ra...

Temporal changes in ocular-surface bacterial contamination during cataract surgery and vitrectomy: effect of povidone–iodine

Postoperative endophthalmitis remains a serious complication of intraocular surgery, and reducing ocular-surface bacterial contamination is an important preventive strategy. We retrospectively evaluated temporal changes in ocular-surface/canthal irrigation-fluid culture positivit...

Comparative Efficacy of Diquafosol, Rebamipide, and Carboxymethylcellulose in Patients with Pre-existing Dry Eye Disease Undergoing Cataract Surgery

Purpose: To compare the clinical efficacy of 3% diquafosol, 2% rebamipide, and 0.5% carboxymethylcellulose (CMC) in patients with pre-existing dry eye disease (DED) undergoing cataract surgery. Methods: This retrospective study included 75 eyes of 75 patients with DED undergoing...

Discordant Antitumor Efficacy with Compromised Survival in High-Risk Unresectable Hepatocellular Carcinoma

Background/Objectives: Real-world data in high-risk patients remain limited; this study evaluated survival, safety, and prognostic factors in this patient group. Methods: This multicenter study retrospectively reviewed 783 patients who received Ate/Bev from 2022–2024 across South...

Age- and sex-adjusted genomic differences between Korean and Beat AML cohorts

Genomic profiling plays a central role in risk stratification and therapeutic decision-making in acute myeloid leukemia (AML), yet the clinical implications of population-specific genomic architectures remain incompletely defined. We conducted a prospective, multicenter study of...

Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

Rapid progression of coronary atherosclerosis is associated with an increased risk of future adverse cardiovascular events. However, evidence regarding the association between glycemic status and rapid plaque progression (RPP) in the major epicardial coronary arteries remains lim...

Exploratory evaluation of an AR-based functional assessment platform in healthy young adults: cross-sectional associations with muscle strength and pulmonary function

Background Augmented reality (AR)-based exercise systems can automatically quantify task performance; however, evidence linking AR-derived metrics with conventional clinical measures remains limited. Objective To explore associations between AR-derived functional task performance...

Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome

Background: Survivors of critical illness commonly experience persistent physical, cognitive, and psychological impairments, collectively known as post–intensive care syndrome. Although intensive care unit (ICU) rehabilitation is now recognized as an important part of recovery af...

Comparative Clinical Outcomes of Various Colorectal Endoscopic Submucosal Dissection Techniques: A Systematic Review and Network Meta-Analysis

Background/Aims: Traction-assisted endoscopic submucosal dissection (T-ESD), hybrid ESD (H-ESD), pocket-creation method ESD (P-ESD), and underwater ESD (U-ESD) were introduced to overcome the limitations of conventional ESD (C-ESD). We conducted a systematic review and network me...

Risk Factors for Stereoacuity Impairment in Intermittent Exotropia: Results from a Nationwide Korean Study

Purpose: To identify clinical factors associated with stereoacuity impairment in patients with intermittent exotropia (IXT), with an emphasis on perinatal, refractive, motor, and sensory parameters. Methods: This nationwide cross-sectional study analyzed 5,385 Korean patients wit...

Clinical Characteristics and Outcomes of Pediatric Patients With Long QT Syndrome: A Korean Multicenter Cohort Study

This multicenter nationwide cohort study comprehensively analyzed the clinical features, genetic architecture, and outcomes of Korean pediatric patients with long QT syndrome (LQTS).Prolonged QT intervals, fetal arrhythmia, and LQT2/3 genotypes compared to LQT1 were independent r...

Impact of intertrochanteric bone mineral density on the accuracy of preoperative templating in cementless total hip arthroplasty: a retrospective cohort study of 510 hips

Abstract Background Preoperative templating accuracy in cementless total hip arthroplasty (THA) may be influenced by patient-specific and radiographic factors, yet bone quality has rarely been considered. We hypothesized that bone mineral density (BMD), and particularly intertroc...

Maternal diabetes and childhood cancer risks in offspring: a nationwide cohort study

Maternal diabetes is associated with several adverse childhood outcomes, but its link to childhood cancer remains inconclusive. We investigated this in a nationwide birth cohort using the Korean National Health Insurance database. We analyzed women who delivered singletons betwee...