Pulmonary and Critical Care Associates

No association between smoking and obstructive sleep apnea in men: evidence from middle-aged adults followed into later life

RATIONALE: The relationship between smoking and obstructive sleep apnea (OSA) remains unclear. Observational findings have been inconsistent, and associations may vary depending on study population, design, measurements. OBJECTIVES: To evaluate the cross-sectional and longitudina...

T cell–intrinsic AIM2 exacerbates lung inflammation in OVA-LPS- and HDM-induced asthma models

Asthma is a heterogeneous inflammatory airway disease characterized by immune dysregulation, airway hyperresponsiveness (AHR), and excessive immune activation. Although NLRP3 (NOD-like receptor family pyrin domain-containing 3) has been extensively studied in asthma, its role rem...

Diagnostic Yield and Molecular Testing Adequacy of Transbronchial Cryoprobe Biopsy Versus Needle Aspiration in Robotic Bronchoscopy

BACKGROUND: In the AQuIRE trial, most cases (83.6%) did not involve transbronchial needle aspiration (TBNA), often underutilized due to challenges in accessing peripheral pulmonary lesions (PPLs). Advances in robotic bronchoscopy with shape-sensing technology (ssRAB) have mitigat...

Flumazenil Use in Benzodiazepine-Induced Delirium Reversal.

Delirium is a frequent and serious complication in critically ill patients, associated with increased mortality, prolonged hospitalization, and long-term cognitive impairment. The hypoactive subtype is particularly underrecognized, missed in up to 75% of cases, and carries worse...