Pulmonary and Allergy Associates

Race and Ethnicity Are Associated With Physical Impairment Among ICU Survivors

Objectives: To evaluate whether race and ethnicity are associated with increased odds of physical impairment among post-ICU survivors and to assess how impairment influences healthcare utilization after hospital discharge. Design: This was a retrospective cohort study. Setting: T...

Prioritizing Global Health Education in Pulmonary and Critical Care Fellowships: An Applicant Survey

Abstract Background Global Health (GH) is expanding, offering an increasing number of opportunities for engagement to trainees in medical schools and residency programs. This expansion of opportunities has not yet reached those at the fellowship level, particularly in Critical Ca...

Budget Impact Analysis of Gene Therapies for Recessive Dystrophic Epidermolysis Bullosa

This economic evaluation investigated the budget impact associated with gene therapy treatment of autosomal recessive dystrophic epidermolysis bullosa.

Perceptions of Incidental Findings on Lung Cancer Screening Exams: A National Survey of Primary Care Clinicians and Radiologists

RATIONALE: Unlike other common cancer screenings, annual lung cancer screening often identifies a spectrum of incidental findings unrelated to lung cancer. While these findings could be actionable, how to best communicate and manage them can be a challenge, often falling upon pri...

Tozorakimab to Prevent COPD Exacerbations

BACKGROUND: Many patients with chronic obstructive pulmonary disease (COPD) have exacerbations despite receiving standard-of-care inhaled maintenance therapy. Dysregulated interleukin-33 signaling is implicated in the pathogenesis of COPD. Tozorakimab is a monoclonal antibody tha...

Budget impact analysis for albuterol–budesonide fixed-dose combination in the as needed treatment of adult patients with asthma in Kuwait

INTRODUCTION: This study assessed the budget impact, from the perspective of the Kuwaiti healthcare payer, of introducing an as-needed fixed-dose combination of albuterol and budesonide (alb/bud-FDC) compared with albuterol alone and ICS-SABA for the management of asthma. METHODS...

Plateau Pressure Exceeding Peak Inspiratory Pressure During Pressure Mode Ventilation With Active Inspiratory Effort

Background In patients receiving pressure modes of mechanical ventilation, plateau pressure can be higher than peak inspiratory pressure when the patient has a strong drive to breathe. This report provides comprehensive evidence to support this observation. Methods Peak inspirato...

Impact of Highly Effective Modulator Therapy on Olfactory‐Specific Gene Expression in People With Cystic Fibrosis

ABSTRACT Background Chronic rhinosinusitis is common in people with cystic fibrosis (PwCF). Highly effective modulator therapy (HEMT) has been shown to improve sinonasal outcomes. However, prior studies failed to show improvement in objective olfaction with HEMT, and the impact o...

Autonomous Oxygen Titration for Maintaining Normoxemia in Acutely Ill Adults

Importance For acutely ill adults who are hospitalized with hypoxemia, supplemental oxygen is titrated to maintain normoxemia. In current practice, clinicians intermittently titrate oxygen, potentially exposing patients to hypoxemia and hyperoxemia between assessments. Autonomous...