Puer University

Electrochemical Sequential Cross-Dehydrogenative Coupling for the Chemoselective Synthesis of Bis(arylthio)-Substituted Biphenyl Diamines

Abstract Controlling C–C and C–S bond formation in one oxidative operation remains challenging because the two coupling modes compete and thiols are prone to overoxidation. Herein, we report an oxidant- and transition-metal-catalyst-free electrochemical strategy for synthesizing...

Plant functional trait and plant–microbe network β-diversity dominate spatial turnover of ecosystem multifunctionality in subtropical forests

Intensified human activities and climate change are accelerating biodiversity loss and the degradation of ecosystem functions. While the positive role of local (α-scale) biodiversity in sustaining ecosystem multifunctionality is well established, its drivers at broader spatial (β...

Taxonomic insights and preliminary enzyme assays of Rhytidhysteron species (Hysteriales, Hysteriaceae) from litter layer in the Yuan Jiang savanna, China

Six terrestrial hysteriaceous fungi were collected from litter in dry-hot valleys, China, all exhibiting the typical morphological characteristics of the genus Rhytidhysteron. Detailed morphological examimation combined with RAxML phylogenetic analysis of combined LSU, SSU, ITS,...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Buffering digital risk: the moderating role of education in the ICT–suicide mortality interface

The expansion of education and the rapid advancement of Information and Communication Technology (ICT) have fundamentally reshaped the socioeconomic determinants of mental health. However, the complex interplay between these two forces in shaping suicidal behavior remains underex...

Complete genome-derived metabolic interactions reveal the impact of gut ecology on human health

Abstract Metabolic interactions govern gut microbiome assembly, yet functional rules remain obscured by genomic incompleteness and fragmentation. Here, we leverage 1,150 complete genomes to construct genome-scale metabolic models, demonstrating that draft genomes introduce system...

Fe(III)-MediatedOxidative [5 + 1] Cyclization forthe Highly Site-Selective Synthesis of Functionalized Quinoline Derivatives

Abstract We describe a method for the construction of highly functionalized quinoline derivatives from enaminones via an oxidative [5 + 1] cyclization. A plausible mechanism may involve a cascade sequence including single-electron transfer (SET), radical Michael addition, elimina...

A cilia-associated epithelial alteration axis nominates ERICH3 as an entry point to PI3K engagement in lung adenocarcinoma

LUAD adopts heterogeneous oncogenic signalling states, and bias toward a PI3K–AKT–mTOR–engaged state is not fully explained by canonical pathway lesions. Because membrane-proximal spatial organization can tune receptor-proximal signalling yet is difficult to quantify in human tum...