Pudong New Area People's Hospital

DNA-Encoded Binding Affinity Shapes Robust CTCF Occupancy Across Cellular Contexts

CCCTC-binding factor (CTCF) is an architectural protein that organizes 3D genome architecture by binding to tens of thousands of genomic loci in a typical human cell type. Although DNA-binding affinity contributes to CTCF occupancy in vivo, the principles distinguishing robust fr...

Puerarin‑Loaded pH‑Responsive ZIF‑90 Nanoparticles Ameliorate Osteoporosis via Enhancing H3K18 Lactylation and Suppressing Aberrant Osteoclast Activation

ABSTRACT Osteoporosis is characterized by dysregulated osteoclast activity, leading to excessive bone resorption and structural damage. In this study, we developed pH‐responsive ZIF‐90 nanoparticles loaded with puerarin (PU) (ZIF‐90@PU) for microenvironment‐responsive osteoporosi...

The effects of dexamethasone on the behavior and neurotransmitters of asthmatic model mice

Patients with acute asthma frequently present with both neurological and psychological manifestations. Changes in neurotransmitter levels may provide objective indicators for assessing behavioral status. This study was conducted to investigate the effects of dexamethasone on moto...

Thoracolumbar fascia injury and other independent predictors of long-term residual low back pain 3 months after percutaneous kyphoplasty for thoracolumbar osteoporotic vertebral compression fractures

To identify independent risk factors for persistent residual low back pain at 3 months after isolated percutaneous kyphoplasty (PKP), and provide standardized clinical evidence for preoperative high-risk patient screening, standardized intraoperative manipulation, and long-term p...

Effect of SEEKflex-guided versus conventional intubation on hemodynamic responses in elderly hypertensive patients: a randomized controlled trial

In elderly patients with preexisting cardiovascular and cerebrovascular diseases, laryngoscopy and tracheal intubation can provoke substantial hemodynamic disturbances, including hypertension and tachycardia, which may precipitate major cardiovascular or cerebrovascular events an...

An iguratimod prodrug reduces RA-FLS invasiveness by disrupting STAT1–C3–TNFα-mediated crosstalk between fibroblast-like synoviocytes and macrophages

Background Rheumatoid arthritis (RA) is driven in part by hyperactivated fibroblast-like synoviocytes (FLS) that invade articular structures. Iguratimod (IGU), a conventional synthetic DMARD, is clinically effective, but its direct molecular target and impact on synovial cell-cel...