Pudong New Area People's Hospital

Effect of SEEKflex-guided versus conventional intubation on hemodynamic responses in elderly hypertensive patients: a randomized controlled trial

In elderly patients with preexisting cardiovascular and cerebrovascular diseases, laryngoscopy and tracheal intubation can provoke substantial hemodynamic disturbances, including hypertension and tachycardia, which may precipitate major cardiovascular or cerebrovascular events an...

An iguratimod prodrug reduces RA-FLS invasiveness by disrupting STAT1–C3–TNFα-mediated crosstalk between fibroblast-like synoviocytes and macrophages

Background Rheumatoid arthritis (RA) is driven in part by hyperactivated fibroblast-like synoviocytes (FLS) that invade articular structures. Iguratimod (IGU), a conventional synthetic DMARD, is clinically effective, but its direct molecular target and impact on synovial cell-cel...