Pudong Medical Center

Social determinants of health substantially enhance identification of high-risk CKM syndrome progression: a longitudinal prediction study based on data from CHARLS

Cardiovascular-Kidney-Metabolic (CKM) syndrome represents a critical public health challenge, with a large portion of the Chinese population classified as CKM Stage 2. While the impact of Social Determinants of Health (SDoH) on chronic disease is known, their longitudinal role in...

A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice

Slow nasal breathing alleviates negative moods, but the precise nose-to-limbic pathways and their causal contributions remain unclear. Here, we identify a pathway in mice from olfactory sensory neurons (OSNs) in the nasal cavity to mitral cells in the olfactory bulb (OB), then to...

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Sepsis associated-acute kidney injury (SA-AKI), a severe complication of sepsis, is characterized by impaired tubular injury that can ultimately cause renal failure and patient mortality. Both histone and non-histone lactylation and cellular PANoptosis have been implicated in the...

Integrating a Ripple Filter into Pencil Beam Scanning Proton Therapy for Breast Cancer: from Dosimetric Feasibility to Acute Toxicity Assessment

Pencil beam scanning (PBS) proton therapy (PT) offers superior dosimetric advantages for breast cancer treatment. However, synchrotron-based facilities frequently encounter throughput limitations due to slow energy layer switching, particularly problematic for superficial targets...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

Dental caries among 12-year-old adolescents in shanghai: a cross-sectional study on prevalence, severity, and associated risk factors

This study aimed to assess the prevalence, severity, and associated factors of dental caries in permanent teeth among 12-year-old adolescents in Shanghai, China. A cross-sectional study was conducted in 2021 among 1,305 adolescents from six randomly selected districts. Clinical e...

A scoping review of patient self-disclosure assessment tools in healthcare settings

To conduct a scoping review of patient self-disclosure assessment tools both domestically and internationally, and to provide a reference for the selection of clinical assessment tools or related research. This scoping review was conducted in accordance with the methodological fr...