Pudong Medical Center

CRIF1 promotes aggressive phenotypes and is associated with reduced paclitaxel-induced apoptosis in endometrial cancer cells through Wnt/β-catenin-related signaling

Endometrial cancer (EC) is a common gynecological malignancy, and chemoresistance remains a major challenge in advanced-stage diseases. CR6-interacting factor 1 (CRIF1) has been implicated in cancer progression; however, its role in EC and paclitaxel response is unclear. CRIF1 ex...

Development and validation of a multiplex targeted PCR-sequencing assay for opioid pharmacogenes genotyping

Interindividual variability in opioid analgesic efficacy and susceptibility to adverse effects is substantially influenced by genetic polymorphisms in pharmacokinetic and pharmacodynamic pathways. However, simultaneous detection of multiple predefined opioid-related variants with...

Multi-omics and spatial transcriptomics reveal that S100A10 drives CD8+ T-cell exhaustion and immune evasion in hepatocellular carcinoma through cPLA2-5-LOX-mediated arachidonic acid metabolism and ferroptosis

Immune evasion in hepatocellular carcinoma (HCC) represents a major biological barrier limiting the efficacy of immunotherapy, yet its molecular basis remains incompletely understood. Increasing evidence indicates that tumor metabolic reprogramming and ferroptosis-related signali...

Electrical Pudendal Nerve Stimulation as an Initial Neuromodulation Strategy for Neurogenic Urinary Retention

Background and objective Chronic neurogenic urinary retention often requires assisted emptying and remains challenging to treat. We evaluated whether electrical pudendal nerve stimulation (EPNS) improves bladder emptying and compared short-term outcomes with a standard sacral neu...

Cryo-EM structures of Cdr1 reveal snapshots of substrate transport and diverse inhibitor recognition

In Candida albicans —a World Health Organization fungal priority pathogen—overexpression of the adenosine triphosphate (ATP)–binding cassette transporter Cdr1 drives multidrug resistance. We present seven cryo–electron microscopy structures capturing substrate entry and expulsion...

Social determinants of health substantially enhance identification of high-risk CKM syndrome progression: a longitudinal prediction study based on data from CHARLS

Cardiovascular-Kidney-Metabolic (CKM) syndrome represents a critical public health challenge, with a large portion of the Chinese population classified as CKM Stage 2. While the impact of Social Determinants of Health (SDoH) on chronic disease is known, their longitudinal role in...

A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice

Slow nasal breathing alleviates negative moods, but the precise nose-to-limbic pathways and their causal contributions remain unclear. Here, we identify a pathway in mice from olfactory sensory neurons (OSNs) in the nasal cavity to mitral cells in the olfactory bulb (OB), then to...

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Sepsis associated-acute kidney injury (SA-AKI), a severe complication of sepsis, is characterized by impaired tubular injury that can ultimately cause renal failure and patient mortality. Both histone and non-histone lactylation and cellular PANoptosis have been implicated in the...

Integrating a Ripple Filter into Pencil Beam Scanning Proton Therapy for Breast Cancer: from Dosimetric Feasibility to Acute Toxicity Assessment

Pencil beam scanning (PBS) proton therapy (PT) offers superior dosimetric advantages for breast cancer treatment. However, synchrotron-based facilities frequently encounter throughput limitations due to slow energy layer switching, particularly problematic for superficial targets...

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Abstract Gestational diabetes mellitus (GDM) reflects metabolic dysregulation that becomes clinically apparent during pregnancy and shares key pathophysiological features with broader forms of diabetes. Gut microbiome‐host metabolic interactions may contribute to this process, ye...

Dental caries among 12-year-old adolescents in shanghai: a cross-sectional study on prevalence, severity, and associated risk factors

This study aimed to assess the prevalence, severity, and associated factors of dental caries in permanent teeth among 12-year-old adolescents in Shanghai, China. A cross-sectional study was conducted in 2021 among 1,305 adolescents from six randomly selected districts. Clinical e...

A scoping review of patient self-disclosure assessment tools in healthcare settings

To conduct a scoping review of patient self-disclosure assessment tools both domestically and internationally, and to provide a reference for the selection of clinical assessment tools or related research. This scoping review was conducted in accordance with the methodological fr...