Public Health Service of Amsterdam

Towards a suitable biomarker for childhood screening for familial hypercholesterolemia: a systematic literature review

Familial hypercholesterolemia (FH) is a common genetic disorder causing elevated low-density lipoprotein cholesterol (LDL-c) concentrations from birth, resulting in a high risk of premature cardiovascular disease. Despite effective early treatment, FH remains underdiagnosed in ch...

Prevalence and associated risk factors of anal high-risk human papillomavirus infection in unvaccinated young men who have sex with men visiting the Center of Sexual Health of Amsterdam

Background: Anal high-risk human papillomavirus (hrHPV) is highly prevalent among men who have sex with men (MSM) and the main cause of anal cancer. The effectiveness of HPV vaccination in this population is highly dependent on prior HPV exposure. We aimed to assess the prevalenc...

Connecting the dots; disseminated histoplasmosis mimicking an infliximab-induced sarcoid-like reaction in anti-PL7 antisynthetase syndrome —a case report

Histoplasmosis is a fungal infection caused by Histoplasma capsulatum . Immunosuppressed patients are at risk of developing severe disseminated disease. We report a case of disseminated histoplasmosis resulting most likely from reactivation of a latent infection more than four de...

Increasing topical sunscreen use in German outdoor workers: results of a non-randomised controlled intervention study

BACKGROUND: Occupational exposure to solar ultraviolet radiation (UVR) is a major environmental risk factor for skin cancer. Outdoor workers accumulate high lifetime UVR exposure and therefore face an increased risk of developing actinic keratoses and skin cancer. Despite establi...

The effect of proximity of COVID-19 test facilities on test uptake: two quasi-experimental trials

Access to testing sites is a critical component in reducing the spread of a virus during infectious disease outbreaks. For example, distance to the testing site has been mentioned as an important self-reported barrier for test uptake during the COVID-19 pandemic. Despite its impo...

Interventions to reduce diabetes-related distress among adults with type 1 and type 2 diabetes: protocol for a systematic review and meta-analysis

Diabetes distress (DD) refers to the emotional and psychological burden experienced by individuals living with diabetes. Randomized controlled trials (RCTs) have investigated the efficacy of interventions on DD among adults with type 1 diabetes or type 2 diabetes. We aimed to sys...

Long-Term Health-Related Quality of Life Outcomes in Patients With Cellulitis Requiring Hospitalisation

In 94 hospitalised patients with cellulitis, HRQoL was markedly impaired at admission and remained significantly below population norms at 90 days, particularly in patients with persistent pain and oedema. These findings highlight the need for post-discharge follow-up focused on...

Effect of EMDR for reduction of pain interference in children with sickle cell disease, the RELAX study: a randomized controlled trial protocol

BACKGROUND: Children with sickle cell disease (SCD) suffer from vaso-occlusive crises, extremely painful episodes that may require hospitalization. Traumatic experiences during hospitalization and frequent pain experiences may lead to psychological distress and the development of...

Divergent complication patterns of type 2 diabetes in African individuals who are lean versus overweight or obese: a multi-cohort analysis

Abstract Aims/hypothesis Nearly 40% of African adults with type 2 diabetes are lean (BMI <25 kg/m 2 ). Emerging evidence suggests that type 2 diabetes in African individuals who are lean may represent a distinct phenotype driven by impaired insulin secretion rather than insulin r...

High-Risk Clones of Carbapenem-Resistant Pseudomonas aeruginosa in India: Genome and Traits

Pseudomonas aeruginosa is a notorious opportunistic pathogen constituting a major cause of health care-associated infections worldwide. Intrinsic resistance to multiple antibiotics, with acquired resistance mechanisms and hypervirulence make it a critical target for genomic inves...

Parent Mental Health From Preterm Birth Through the NICU Stay

OBJECTIVES: Preterm birth and neonatal intensive care unit (NICU) admission are not only extremely stressful for the infant itself but can also impact parental mental health. This Dutch national prospective cohort study aimed to describe the trajectory of parental mental health f...

Navigating regulatory scenarios for accelerating drug repurposing in rare diseases: a multi-stakeholder perspective on the challenges and opportunities

<title>Abstract</title> Background: The lack of treatments for patients with a rare disease calls for innovative approaches in drug development. A potential solution to accelerate therapy development is to find new therapeutic uses for existing drugs, i.e. drug repurposing. One w...

Histoplasmosis in India: a systematic review of reported cases

BACKGROUND: Histoplasmosis is a systemic fungal infection caused by Histoplasma capsulatum and is increasingly recognised in India, but its epidemiology, clinical spectrum, diagnosis, treatment, and outcomes remain poorly characterised. We conducted a systematic review of reporte...

Measuring healthcare quality in police custody: the development of quality indicators through expert consultations in the Netherlands

Abstract Background Improving the quality of care for people detained in police custody requires careful measurement and monitoring. However, a standardized and endorsed set of quality indicators for healthcare in police custody settings is lacking. This study aimed to develop a...