ProterixBio (United States)

Crystal Structureof the Sigma-2 Receptor Complexedwith Investigational Drug Zervimesine (CT1812)

Abstract The investigational drug zervimesine (CT1812) is an allosteric small molecule modulator of the sigma-2 receptor (S2R), known as transmembrane protein 97 (TMEM97), currently in clinical development for Alzheimer’s disease and dementia with Lewy bodies. In Phase 2 trials,...

Facile, high‐throughput protein purification enabled by high‐efficiency protease elution

Abstract While advances in artificial intelligence have made protein design widely accessible, protein production and characterization remain a bottleneck. Protease‐cleavable affinity tags are commonly used to improve yield and purity of recombinant proteins, but tag removal adds...