Princess Alexandra Hospital

First-in-Human Permanent Totally Leadless Left Ventricular Septal Endocardial Pacing With Atrioventricular Synchrony.

BACKGROUND: Leadless cardiac resynchronization combining WiSE system ultrasound-mediated left ventricular pacing with leadless right ventricular pacing has been reported. However, atrioventricular-sequential left ventricular pacing triggered by atrial leadless pacing impulse with...

RINGSIDE Phase II Study of Varegacestat for Treatment of Desmoid Tumors: A Randomized Dose-Finding Clinical Trial

PURPOSE Desmoid tumors (DTs) are rare, often locally aggressive, connective tissue neoplasms with limited effective treatment options. We evaluated the safety and efficacy of varegacestat, an oral gamma-secretase inhibitor. METHODS RINGSIDE phase II was an open-label, randomized,...

Choroidal Melanoma Treated With Ruthenium‐106 Eye Plaque Brachytherapy: Results of an Australian Statewide Service From November 2020 to January 2025

ABSTRACT Introduction Uveal melanoma is a rare but aggressive malignancy, predominantly affecting the choroid. This study is the first retrospective review performed on adult choroidal melanoma patients treated with Ruthenium‐106 plaque brachytherapy in Queensland. Method The stu...

A conical-reflector scintillation device for 3-dimensional measurement of radiotherapy beams: a feasibility study

Abstract This study presents a novel optical dosimetry system designed to support three-dimensional characterisation of radiotherapy beams using a single-camera imaging geometry. The system combines a large-volume cylindrical plastic scintillator with a conical reflector, enablin...

Clinical characteristics and semiological pitfalls in patients with focal epilepsy and functional/dissociative seizures: A comparative analysis of correct and incorrect initial diagnoses

OBJECTIVE: Both epilepsy and functional/dissociative seizures (FDS) can present with a wide variety of event manifestations which can appear similar in nature and contribute to misdiagnosis. Whereas many studies have addressed the misdiagnosis of FDS as epilepsy, research into th...

The feasibility of a tailored follow-up service for people living with stroke via a registry-based randomised controlled trial (A-LISTS)

After stroke, people report ongoing health challenges to national registries without any follow-up. We aimed to assess the feasibility of a co-designed, registry-initiated, follow-up service provided by hospitals and tailored for people reporting health-related challenges between...

Lenalidomide maintenance after initial immunochemotherapy in chronic lymphocytic leukaemia—Final analysis of the international phase III CLL6 RESIDUUM study of the ALLG and FILO groups

Summary Most patients treated for chronic lymphocytic leukaemia (CLL) fail to achieve measurable residual disease (MRD) negativity. The role of maintenance with the immunomodulatory drug lenalidomide in these patients is unclear. A randomised multicentre phase III trial (ACTRN126...

Effects of continuing or withholding angiotensin axis blockers prior to elective surgery: The PAAB randomized clinical trial

Abstract Background Current guidelines favour preoperative withholding of angiotensin‐axis blockers (AABs) in patients without hypertension or systolic heart failure to decrease peri‐operative cardiorenal risk, although evidence of such effects is lacking. Objective To assess rat...

First-in-human experience from RESET-AF (Rapid onE-Shot Electroporation Trial for Atrial Fibrillation)

Abstract Background and Aims Pulsed field ablation (PFA) is increasingly used to treat patients with atrial fibrillation (AF). The RESET-AF was a single-arm, first-in-human, clinical trial of AF ablation using a novel, single-shot PFA system (ElePulse ® , CRC EP, Tustin, CA, USA)...

Impact of LIFE training on educational staff’s suicide prevention skills and confidence levels

Purpose This study aims to assess the impact of LIFE training on educational staff’s confidence in communication skills that can support students in suicidal distress. Design/methodology/approach LIFE training is a school-based suicide prevention course designed to develop educat...

Implementing univerSal TeleprehabiliTation into cAnceR caRe pathwayS (STTARRS Trial): protocol for a hybrid type 1 multi-centre randomised controlled trial and nested sub study

Abstract Background Postoperative complications are common after major cancer surgeries, occurring in 25–50% of patients. They delay recovery and adversely affect both cancer-free and overall survival. Intervention to optimise patients’ physical and psychological wellbeing before...

The role of hSSB1 and hSSB2 in the DNA damage response: mechanisms and implications

Abstract The DNA damage response preserves genome integrity by detecting DNA lesions, activating checkpoint signalling, and coordinating repair with cell-cycle control. Defective or incomplete repair can promote mutation accumulation, chromosomal instability, cancer development,...

Validation of a Three‐Dimensional Handheld Scanner in Measuring Breast Anthropometrics

ABSTRACT Background Outcomes in aesthetic breast surgery are dependent on accurate pre‐operative breast measurements. The accuracy of large scale 3‐dimentional scanners has been reported, the use of handheld scanners has not been described. Objectives The authors aimed to determi...

P1.144. Preoperative Biochemical and Micronutrient Abnormalities in Oesophagogastric Surgery

Abstract Topic Esophageal Cancer: Other Background Preoperative micronutrient and biochemical abnormalities are common in patients undergoing oesophagogastric surgery. Routine laboratory panels are frequently ordered indiscriminately despite variable diagnostic yield, and the fre...

Outcomes after discharge from acute hospital to residential aged care among long-stay inpatients: a retrospective cohort study using a health service long-stay dashboard

OBJECTIVE: This study aimed to describe pathway timing and 90-day outcomes for long-stay inpatients discharged to residential aged care homes (RACHs), predominantly new entrants, and to explore potentially modifiable factors associated with delays and the composite unsuccessful p...

Scaling up Genomics

Introduction: Genomic testing has substantial diagnostic and clinical value in nephrology, yet integrating testing into routine care requires service-level changes to ensure timely and equitable access. Methods: We conducted an observational cohort study at four tertiary centres,...

Measuring Safer Opioid Use in Hospitals: Development of Consensus-Based Safety and Quality Indicators - a modified Delphi study

BACKGROUND: A significant contributor to preventable medication related harm is opioids. Within Australian hospitals, opioids have contributed to deaths, hospital admissions, and in-hospital related harm. Given these harms, there is a need to ensure opioids are used safely and th...

Effect of Testosterone Treatment on Leucocyte Telomere Length in Men: Results From a Randomised Placebo‐Controlled Trial

BACKGROUND: Lower testosterone concentrations in older men are associated with poorer health outcomes. OBJECTIVE: We examined whether, on a background of lifestyle intervention, testosterone treatment modulates leucocyte telomere length, a postulated marker of biological ageing,...

Fibrinogen Early In Severe Trauma studY II (FEISTY II): study protocol for a randomised clinical trial of fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in Australia and New Zealand

Haemorrhage is a leading cause of preventable death amongst severe trauma patients and is often complicated by hypofibrinogenaemia. Fibrinogen replacement can be achieved using fibrinogen concentrate (FC) or Cryoprecipitate (Cryo), but comparative evidence in traumatic haemorrhag...

Co-designing ‘Focus on Frailty’, a digital frailty education course for hospitals: a qualitative study of healthcare professionals’ perspectives

Frailty is associated with negative outcomes and adverse events in hospitals; however, limited formal education on frailty exists in this setting. Healthcare professionals across disciplines have expressed a need and want for frailty education and training. This study aimed to ex...