Prince of Wales Hospital

Clinical Outcome Differences in Asia Versus Non-Asia Intracerebral Hemorrhage: IPD Analysis From BP-Lowering Clinical Trials

BACKGROUND: Evidence of regional differences in clinical outcomes after intracerebral hemorrhage (ICH) is still scarce. We quantified differential outcomes and response to early intensive blood pressure lowering treatment by region in the Blood pressure in Acute Stroke Collaborat...

Heritability of Fruit and Vegetable Consumption and Depressive Symptoms in Community-Based Middle-Aged and Older Adults from Four International Twin Cohorts

Fruit and vegetable intakes have been associated with reduced risk of depressive symptoms in observational studies, potentially due to anti-inflammatory properties, micronutrient content, and effects on the gut-brain axis. Understanding the genetic and environmental influences on...

Prehospital Stroke Treatment Trials in Conventional EMS Settings: An Expert Consensus Statement on Operational, Ethical, and Technological Priorities

Prehospital stroke trials enable assessments of ultraearly administration of treatments and management strategies, but face unique challenges in their design, conduct, and analysis. We outline important considerations and recommendations for planning prehospital stroke trials, fo...

The role of fenestration in acute canine thoracolumbar intervertebral disc extrusion: Part 2—The biological and biomechanical effects of fenestration

Abstract Background Prophylactic fenestration is widely performed to prevent recurrence of canine acute thoracolumbar intervertebral disc extrusion (IVDE); however, there is a paucity of specific data regarding the biological and biomechanical effect of this procedure on the inte...

Lived experience leadership in cancer research: a scoping review of conceptual definitions, roles, responsibilities, and impacts

Abstract Background The meaningful integration of lived experience expertise into cancer research is increasingly recognized as essential to improving research relevance, quality, and impact. However, the extent to which people with lived experience of cancer hold leadership role...

Combining Implementation and Data Sciences to Accelerate Evidence Integration into Healthcare – ImpleMATE

Background The translation of research evidence into routine healthcare practice is often slow and inconsistent, even timely implementation can significantly improve patient outcomes. While implementation science offers strategies to close this gap, current approaches are frequen...

Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex

Muscle synergies extracted from multimuscle electromyographic (EMG) signals are widely interpreted as fundamental building blocks of motor control that coordinate groups of muscles during movement. Whether EMG-derived muscle synergies represent genuine neurally encoded modules or...

Efficacy and safety of canagliflozin are consistent across polypharmacy burden in CKD: the CREDENCE trial

Abstract Background Polypharmacy in chronic kidney disease (CKD) is substantial. Clinicians and patients are often reluctant to add medications to already complex regimens, partly due to concerns about diminishing efficacy and increased adverse effects. We assessed whether effica...

HITH4HIPs: a feasibility trial of hospital in the home after hip fracture

In Australia, as in many other jurisdictions, people with low-trauma hip fractures often stay in hospital for extended periods, even when medically stable, increasing risk of hospital-related complications and increasing healthcare costs. In this context, we sought to determine t...

Model 1b analytical performance specifications – report on the Prague 2025 workshop

diagnostic medical devices (IVD MD) meet regulatory and quality standards before market release; for external quality assurance assessments; for quality control, monitoring reagent lot-to-lot variability, and allowing preanalytical variation assessments in labs; and for guiding p...

Impact of respiratory muscle training on sleep disordered breathing in people with tetraplegia: a sub-analysis of a randomised controlled trial

<title>Abstract</title> <bold>Study Design:</bold>Sub-analysis of a randomised controlled trial. <bold>Objectives:</bold>Respiratory muscle training (RMT) in people with tetraplegia yields marked improvements in inspiratory muscle strength. The present study investigated whether...

Issues in the clinical assessment and management of people living with motor neurone disease (MND): a survey of Australian healthcare professionals

Objective: To inform the development of the Australian MND Guideline, this study aimed to identify challenges Australian healthcare professionals (HCPs) face in the clinical assessment and management of people living with MND (plwMND) including where practice varies from evidence...