Prefectural University of Kumamoto

Prior vedolizumab exposure and fibroblast-derived MMP13 are associated with ustekinumab nonresponse in ulcerative colitis

Abstract Background As therapeutic options for ulcerative colitis increase, optimizing the sequencing of advanced therapies has become an important challenge. We examined whether baseline clinical characteristics influence the effectiveness of ustekinumab and investigated molecul...

Gut microbial phenol impairs energy metabolism and promotes sarcopenic obesity-like phenotypes in mice

Abstract Gut microbial phenol has been recognized as a uremic toxin associated with chronic kidney disease; however, its effects under preclinical conditions remain unclear. In this study, we established a mouse model with increased endogenous phenol production using a tyrosine-r...

The Shape-SelectiveSuspension–Deposition Differentiationof Microplastics in an Air–Snow System: Insights from a NortheasternPolluted City in China

Abstract Atmospheric microplastics (MPs) are increasingly recognized as important atmospheric pollutants, yet the role of particle physical properties in their suspension–deposition differentiation remains unclear. Here, MPs were simultaneously investigated in 31 total-suspended-...