Precision Therapeutics (United States)

Prognostic significance and molecular implication of microRNAs in hepatocellular carcinoma following curative surgical resection

Although various advanced therapeutic strategies exist for hepatocellular carcinoma (HCC), it continues to rank among the primary drivers of cancer-related fatalities worldwide. Resection surgery offers a cure for HCC, but a high recurrence rate severely limits patient survival....

Discovery of Tetrasubstituted Quinazolin-4(3 H )-ones as Wild-type-sparing, Highly Selective PI3KαH1047R Inhibitors

Abstract Inhibiting PI3Kα has demonstrated promising therapeutic effects for patients with HR+/HER2− and PIK3CA-mutated advanced or metastatic breast cancer. However, hyperglycemia and other notable adverse events (AE) associated with concomitant wild-type inhibition remain a cha...

International Society of Urological Pathology Multidisciplinary Expert Consultation Conference on Evaluation of Treatment Effects in Prostate and Bladder Cancer

Treatment effects in the urinary bladder are variable and range from localized post-transurethral resection changes to widespread systemic therapy effects. The International Society of Urological Pathology (ISUP) organized a consensus meeting in Vienna, Austria, in September 2025...