Precision Research (United States)

Systematic opto-mechanical design approach for meter-long Nano-AKB mirror system at HEPS

A systematic opto-mechanical design approach is developed for a long Nano-AKB mirror system aimed at stable sub-50 nm hard X-ray nanofocusing. The approach integrates deformation–stiffness-balanced mirror clamping, hierarchical precision alignment, and thermomechanical stability...

Hunting for microsatellite instability in long-read data with Owl

Abstract Microsatellite instability (MSI) is a key biomarker of mismatch repair deficiency and response to immunotherapy, yet most existing genomic detection methods are optimized for short-read sequencing and rely on small panels of homopolymer markers, limiting the ability to c...

Development of adjuvanted HIV vaccines tailored for early life: immunologic rationale, clinical experience, and future directions

Purpose of review This review highlights the rationale for and clinical experience in advancing age-specific adjuvantation systems to develop well tolerated and effective pediatric HIV vaccines. Recent findings Due to both cellular and soluble factors, infant immunity is distinct...

Machine learning enhanced prediction of optical properties via reverse Monte Carlo method

We present a machine learning (ML) approach for the accelerated extraction of optical properties from the experimental reflection electron energy loss spectroscopy (REELS) spectra by the reverse Monte Carlo (RMC) method. Taking platinum (Pt) as an example, experimental REELS spec...

Calculation of backscattering correction factors in AES for compounds: Unraveling matrix effects

Backscattering correction factor (BCF) data are essential for quantitative Auger electron spectroscopy (AES) analysis. This study computes BCFs for nine oxides and three zinc chalcogenides by using a Monte Carlo method that incorporates dielectric function theory for discrete ine...