Precision for Medicine (United States)

Preliminary clinical changes during use of a personalized video-based mobile intervention for community-dwelling individuals with severe mental illness: An exploratory randomized crossover trial

Severe mental illness (SMI) often limits participation in traditional therapy due to motivational and cognitive deficits. We examined short-term clinical changes during use of a personalized video-based mobile app ( MARO )—providing psychoeducation, emotion regulation, cognitive...

Nascent Extracellular Matrix Converts Biomaterial Cues into Cell Fate Decisions

ABSTRACT Hydrogels serve as powerful models for investigating cell‐extracellular matrix (ECM) interactions. While chemical modifications are routinely used to tune hydrogel properties, it remains unclear whether these modifications mediate cell fate. Previous work has shown that...

65. HIGHER POLY-METHYLATION SCORE FOR SCHIZOPHRENIA IS ASSOCIATED WITH GREATER NEGATIVE SYMPTOM SEVERITY AT 10-YEAR FOLLOW-UP

Background Negative symptoms are among the most disabling features of psychotic disorders and frequently persist over time. Baseline clinical measures (e.g. symptom severity at illness onset) explain only part of the variability in long-term outcomes, highlighting the need for im...

Peptide Fingerprinting of Single Protein Molecules Using In‐Plane Nanopore Sensors Integrated to an Extended Immobilized Nanoscale Enzymatic Reactor (eINER)

ABSTRACT We report a thermoplastic nanofluidic device that combines an extended immobilized nanoscale enzymatic reactor (eINER) with a dual in‐plane nanopore time‐of‐flight (DNP‐ToF) reader for label‐free peptide fingerprinting of single protein molecules. As opposed to tradition...

CO-Mediated Relay Catalysis Affords Selective CO2 Hydrogenation to Methanol

Abstract Although technologically promising for producing petrochemicals directly from renewable resources, CO2 hydrogenation to methanol remains a formidable challenge due to the activity-selectivity trade-off. Current industrial copper-based catalysts often generate substantial...

The Ethics of Growth-Promoting Pharmaceuticals for Achondroplasia

In 2021, vosoritide became the first pharmaceutical approved to treat the pathophysiology of achondroplastic dwarfism. It has generated significant ethical debate. Proponents emphasize its potential to improve quality of life and functional independence, whereas critics raise con...

Surgical Ablation for Atrial Fibrillation During Minimally Invasive Mitral Valve Surgery: Risk Dependencies and Long-Term Survival

Objective: Atrial fibrillation (AF) is a common finding among patients with mitral valve disease, with a growing body of evidence showing survival benefits associated with surgical ablation (SA). However, a lack of data persists regarding the safety and survival after SA concomit...

Phage vB_KpnM_NB cocktail synergizing with amikacin in inhibiting persister cells of Klebsiella pneumoniae

ABSTRACT The emergence of multidrug-resistant Klebsiella pneumoniae (KPN) and antibiotic-tolerant persister cells poses a significant challenge to existing anti-infection therapies. Given the urgent need for sustainable alternatives to antibiotics, phage cocktails are emerging as...

Mechanical cues of an interpenetrating polysaccharide matrix regulate self-assembly of collagen fibers

Collagen molecules self-assemble into supramolecular fibers within a molecularly crowded, polysaccharide-rich extracellular matrix (ECM). The ECM typically has fluid-like, viscoelastic properties that can be quantified rheologically. Here, we determine that the viscoelasticity of...

Longitudinal spatial multi-omics delineates tumor microenvironment remodeling across sequential EGFR-TKIs in EGFR-mutant NSCLC

Abstract Background Resistance to therapy is a frequent occurrence in patients with epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) who are treated with EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, spatial information on how the tumor mi...

Viridicatin from the Antarctic Fungus Penicillium sp. Protects Human Microglia and Patient-Derived Peripheral Immune Cells Against Oxidative Stress

Neurodegenerative diseases remain a major therapeutic challenge, with oxidative stress playing a central role in central and peripheral immune system dysfunction that leads to neuronal loss. Natural products from extreme environments represent an underexplored source of neuroprot...

Experimental and numerical investigation of frictional loss and empirical correlation in Taylor–Couette–Poiseuille flow for a high-speed PMSM with an H2O2-flooded gap

A high-speed permanent magnet synchronous motor (PMSM) used in rocket propellant feed systems generates complex Taylor–Couette–Poiseuille (TCP) flow due to the H 2 O 2 -flooded gap and high rotational speeds, complicating the analysis of motor friction loss. To address this, a th...

The role of chloride ions in serotonin transport

Abstract The human serotonin (5-HT + ) transporter SERT facilitates 5-HT + transport into cells by coupling it to Na + symport and K + antiport. Although extracellular Cl − is also essential for transport, Cl − co-transport has been disputed, raising questions about the role of C...

Epidemiological Characteristics of Pediatric Drug Poisoning in Wenzhou, China in 2017–2024

To examine the evolving epidemiological characteristics of pediatric drug poisoning in Wenzhou, China from 2017 to 2024, focusing on temporal trends, age/sex-specific risks, and changes in poisoning intent and toxin types, and to generate evidence-based guidance for targeted prev...

Genetic Predisposition and Pharmacological Effects Shape the Divergent Effects of Type 2 Diabetes on Atherosclerosis

Abstract Type 2 diabetes mellitus (T2D) increases the risk of atherosclerotic diseases, including coronary artery disease (CAD), but decreases that for abdominal aortic aneurysm (AAA), forming an intriguing diabetes-atherosclerosis paradox. We investigate how genetic underpinning...

ModernizingTraditional Mineral Medicine: Pyrolusite-DerivedMnO2 Nanoplatform for Osteo-Angio-Immunomodulatory BoneRepair

Abstract Pyrolusite, a traditional mineral medicine rich in manganese, has long been used to promote fracture healing; however, its complex composition, limited bioavailability, and poorly defined mechanisms have hindered its modernization and clinical translation. Here, we prese...

Spatially resolved tissue architecture and computational pathology in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a complex disease characterized by high levels of cellular heterogeneity and pronounced microenvironmental remodelling. Dynamic changes during its initiation and progression contribute to resistance to conventional therapies. Building up...

Physically Constrained Dual-Branch Front-End Optimization for DDH-Oriented Surgical Robot Navigation

Surgical robot navigation in a restricted pelvic workspace requires accurate target localization, directional consistency and robot-feasible execution. This study proposes a physically constrained dual-branch front-end network (PCD-Net) for DDH-oriented navigation using public CT...