Postgraduate School of Molecular Medicine

Dietary Modulation of microRNAs as a Potential Nutritional Strategy in Inflammatory and Autoimmune Skin Diseases: A Narrative Review

Inflammatory and autoimmune skin diseases like psoriasis, atopic dermatitis, and hidradenitis suppurativa present significant therapeutic challenges due to their complex immunological and environmental pathogenesis. This review highlights the critical role of microRNAs (miRNAs) a...

Mature Human Milk Macronutrient Composition and Apparent Milk TSH Concentration in Women with Treated Hypothyroidism Attending Lactation Counseling: A Cross-Sectional Study

Background/Objectives: Hypothyroidism may influence lactation physiology, but evidence regarding its association with mature human milk composition remains limited. This cross-sectional study evaluated macronutrient composition and apparent thyroid-stimulating hormone (TSH) conce...

Physical Activity–Sedentary Behaviour Profiles and Co-Occurring Lifestyle Behaviours Among Adolescents: A Person-Oriented Analysis

Background/Objectives: Physical activity and sedentary behaviour are important components of adolescent lifestyle, but favourable movement behaviour may not correspond to favourable behaviours across other health-related domains. This study aimed to identify empirical physical ac...

Emerging Roles of Dystroglycan in Cardiac Remodeling, Fibrosis, and Heart Failure

The dystrophin–glycoprotein complex (DGC) is a structural and signaling network of cardiac muscle. It connects the extracellular matrix to the intracellular cytoskeleton. Dystroglycan, a component of the DGC, plays an essential role in maintaining the integrity of the sarcolemma...

Exploring birth options after three or four cesarean sections in Poland: maternal and neonatal outcomes following vaginal vs repeat surgical deliveries

OBJECTIVES: Postpartum depression (PPD) profoundly affects maternal health and disrupts mother-infant bonding, with lasting effects on infant development. The causal roles of hormones that change most dramatically during the perinatal period, including estradiol, cortisol, and pr...

Crisis Resource Management and Non-Technical Skills Training in Anesthesia: A Narrative Review

Adverse medical events remain a serious concern worldwide; deficiencies in human factors contribute to a large proportion of medical incidents and preventable patient harm.In anesthesiology, where high-risk and complex clinical events are routine, non-technical skills (NTS)-inclu...

Integrated Multi-Omics and Interactome Analysis of CDK8 Inhibition Reveals Erythroid Differentiation Programs and Therapeutic Synergy with BET Blockade in AML

Acute myeloid leukaemia (AML) is a therapeutically challenging malignancy driven by the self-renewal, quiescence, and therapy resistance of leukaemic stem cells (LSCs). CDK8, a kinase component of the Mediator complex, regulates oncogenic transcription, and the selective CDK8/CDK...