Port Said University

Evaluation of sirtuin 1 serum level and gene expression in patients with metabolic syndrome accompanied by metabolic dysfunction-associated steatotic liver disease

Abstract Background Metabolic syndrome is a cluster of conditions, including abdominal obesity, dyslipidemia, hypertension, and impaired glucose metabolism, that significantly increase the risk of cardiovascular disease and type 2 diabetes mellitus (T2DM). Metabolic dysfunction-a...

Beclin-1 and HIF-1α immunohistochemical expression in breast carcinoma: insights into tumor biology

Breast carcinoma is a biologically heterogeneous disease in which tumor behavior and clinical outcome are influenced by multiple cellular pathways, including autophagy and hypoxia. Beclin-1, a key autophagy-related protein, and hypoxia-inducible factor-1α (HIF-1α), a central regu...