Pontifícia Universidade Católica de Campinas

Carcinogenic mechanisms in penile cancer: HPV, inflammation, and other pathways

Objective: Penile cancer, though rare, carries profound clinical and psychosocial consequences. Its diagnosis often occurs at advanced stages, leading to mutilating surgeries and severe impairment in quality of life. Approximately 95% of penile malignancies are squamous cell carc...

Recent advances in protein extraction methods from bone tissue for proteomics analysis

Abstract Proteomic analysis is a fundamental tool for obtaining new information about biological functions that occur at the molecular level in the body, allowing the understanding of physiological and pathological processes, as well as contributing to the diagnosis and preventio...

Hypokalemic Hypochloremic Metabolic Alkalosis in Cystic Fibrosis: A Retrospective Observational Study with Clinical Characterization, CFTR Genetic Profiling, and a Comparative Genetic Analysis with Patients from a Brazilian Reference Center

Cystic fibrosis is a genetic disorder caused by pathogenic variants in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene and may be complicated by hypokalemic hypochloremic metabolic alkalosis (HHMA), resulting from excessive electrolyte loss through sweat. This...

Comparative Study of Myocutaneous Latissimus Dorsi Flap Breast Reconstruction With Implant Versus Lipofilling: Complication Rates and Risk Factors

BACKGROUND: Breast cancer is the most prevalent malignancy among women globally, and mastectomy often forms a critical part of its treatment. Breast reconstruction is an important aspect of post-mastectomy care, contributing to improved psychological well-being and quality of lif...