Ponce Health Sciences University

DNA methylation modulation by 5-Azacytidine regulates EMT markers and reduces invasiveness in docetaxel-resistant prostate cancer cells

<title>Abstract</title> <bold>Background:</bold> Metastatic castration-resistant prostate cancer (mCRPC) is associated with poor prognosis and high mortality, largely due to the emergence of androgen and chemotherapy resistance. Resistance to docetaxel occurs in nearly 50% of pat...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...