Pomeranian Medical University

Associations of IL-2, IL-6 and IL-10 Gene Polymorphisms with Biochemical Parameters and Calcineurin Inhibitor Dosing in Kidney Transplant Recipients

Background/Objectives: Kidney graft dysfunction remains a major challenge limiting long-term transplant survival despite advances in immunosuppressive therapy. Cytokine signaling pathways have been implicated in the regulation of alloimmune responses and chronic inflammation, but...

Multi-Target Modulation of Interconnected Pathogenetic Pathways by Natural Bioactive Compounds in Endometriosis

Background: Endometriosis is a chronic estrogen-dependent disease characterized by the presence of endometrial-like tissue outside the uterine cavity. Its pathogenesis involves interactions between inflammatory, angiogenic, hormonal, oxidative stress-related, and cell survival-as...

Liposomal Formulations Containing Amino Acid Menthol Ester Naproxenate: Physicochemical Characterization and Transdermal Delivery Potential

Non-steroidal anti-inflammatory drugs (NSAIDs), including naproxen, are widely used for the treatment of pain and inflammation; however, their therapeutic application is limited by poor aqueous solubility and low bioavailability. This study aimed to synthesize and characterize a...

Behavioural and systemic correlates of functional tooth loss and exploratory derivation of the Geriatric Oral Health Vulnerability Score (GOHVS) in older adults: a cross-sectional study

Oral health is central to healthy ageing, yet older adults often seek dental care only after substantial deterioration. This cross-sectional study describes oral health status, multimorbidity, and oral hygiene behaviours among first-time dental attendees aged ≥65 years, and exami...

Drug-based ionic derivatives of NSAIDs: influence of cation structure on physicochemical properties, skin permeation, and biocompatibility

Abstract Drug-based ionic systems represent a promising strategy to improve the physicochemical properties and delivery performance of poorly soluble active pharmaceutical ingredients. In this study, ionic derivatives of four nonsteroidal anti-inflammatory drugs (NSAIDs)—ibuprofe...

Intra-Articular Monoclonal Antibodies in Temporomandibular Joint Disorders: Current Evidence

Immune-mediated temporomandibular joint disorders involve cytokine-driven inflammation and may represent a target for biologic therapy. This paper summarizes the evidence on intra-articular monoclonal antibody administration in temporomandibular joint disorders. PubMed, Europe PM...