Pomeranian Medical University

Functional Status, Quality of Life and Survival After Repeated Intrathecal Administration of Autologous Lineage-Negative Cells in Amyotrophic Lateral Sclerosis

Background/Objectives: Adjuvant cell-based strategies are still being explored in amyotrophic lateral sclerosis (ALS). Materials and Methods: In this open-label, single-arm study of intrathecal autologous bone marrow-derived lineage-negative (LIN−) cells, we report functional sta...

Problematic internet use is associated with poorer health behaviours and peripheral serotonin levels in young men

Abstract Problematic Internet Use (PIU) is associated with difficulties in psychological, social, academic, and occupational functioning and is associated with unhealthy behaviours such as poor diet, inactivity, and sleep problems. The post-pandemic period has intensified PIU and...

Disease- and Region-Specific Molecular Patterns Involving miRNAs and Associated Signalling Pathways and Epithelial Cell-Fate Responses in PSC-Associated Ulcerative Colitis

Patients with primary sclerosing cholangitis-associated ulcerative colitis (PSC-UC) have an elevated risk of colorectal cancer compared with ulcerative colitis (UC), but the molecular mechanisms linking chronic inflammation to epithelial cell fate remain unclear. The present stud...

A Novel Interpositional Arthroplasty Technique for Chronic, Painful Thumb Metacarpophalangeal Joint Instability—A Case Report

Background/Objectives: Chronic injuries of the radial collateral ligament (RCL) of the thumb metacarpophalangeal (TMCP) joint are becoming an increasingly common clinical challenge. In cases without degenerative changes, surgical treatment with ligament reconstruction may be effe...

Exercise-Induced Extracellular Vesicle-Associated miRNAs in Cognitive Aging of Older Adults: A Narrative Review

Cognitive aging involves chronic neuroinflammation, microglial dysregulation, vascular dysfunction, oxidative stress, and impaired neuroplasticity, and physical activity is one of the few modifiable interventions known to influence all of these processes simultaneously. The molec...

The Paradox of Medical Education: Lifestyle and the Sense of Self-Efficacy and Locus of Health Control Among Medical Students in the Eastern Borderlands of the European Union

Abstract Aim This cross-sectional study evaluated health behaviors, diet, physical activity, and psychological determinants (self-efficacy, life satisfaction, health locus of control) among medical and health sciences students across seven EU borderland countries to investigate t...

Beyond BMI: The Role of Visceral Adipose Tissue in Cardiometabolic Risk Stratification Among Children and Adolescents with Obesity—A Systematic Review

Background and Objective: Body mass index (BMI) is widely used to classify obesity in children and adolescents but does not characterize fat distribution. Visceral adipose tissue (VAT) may provide information on cardiometabolic risk beyond BMI. This systematic review aimed to syn...

The Role of Non-Coding RNAs in the Pathogenesis of Asthma

Asthma is a chronic inflammatory airway disease characterized by considerable clinical and molecular heterogeneity, involving complex interactions between genetic susceptibility, environmental factors, and immune dysregulation. Increasing evidence indicates that non-coding RNAs (...

Genetic Polymorphisms in Rheumatoid Arthritis: From GWAS-Identified Loci to Functional, Biomarker, and Pharmacogenomic Insights

Rheumatoid arthritis (RA) is a chronic autoimmune disease with a complex, multifactorial aetiology, in which both environmental factors and genetic predisposition play a significant role. This narrative review summarises the genetic polymorphisms associated with RA that have been...

Comments on the systematic review and meta‐analysis by Câmara et al. on second‐generation colon capsule endoscopy

Data sharing not applicable to this article as no datasets were generated or analysed during the current study.

Vitamins in the Management of Inferior Alveolar Nerve Sensory Disturbances: A Scoping Review of Randomized Studies

Background: Sensory disturbances of the inferior alveolar nerve (IAN) may follow dental and maxillofacial procedures and impair oral function and quality of life. This scoping review mapped randomized evidence on vitamin-based treatment of established IAN sensory disturbances. Me...

Smoking behaviours and attitudes among dental students in three European countries: a multicentre cross-sectional study

Tobacco use remains a major public health concern and a significant risk factor for systemic and oral diseases. Dental students, as future healthcare professionals, are expected to play an important role in tobacco control and smoking cessation. This multicentre study aimed to as...

Effectiveness and Safety of Ultrasound-Guided Radiosynovectomy for Persistent Joint Effusion: A Retrospective Single-Center Study

Abstract Purpose Radiosynovectomy is a minimally invasive treatment used in patients with persistent joint effusion associated with synovial hypertrophy, particularly when conventional pharmacological therapy is insufficient. To evaluate the effectiveness and safety of ultrasound...

RED-S IN ENDURANCE ATHLETES — SKELETAL CONSEQUENCES OF CHRONIC LOW ENERGY AVAILABILITY

Background. Relative Energy Deficiency in Sport (RED-S) is an increasingly recognized health problem among endurance athletes. The main mechanism leading to the development of RED-S is low energy availability (LEA), resulting from insufficient energy intake in relation to exercis...

Longitudinal Changes in QTc Interval in Cancer Patients After the Initiation of Systemic Therapy: Analysis of the ONCOECHO Study Cohort

Background/Objectives: Anticancer therapies are associated with a prolongation of QT interval of electrocardiogram (ECG), increasing the risk of arrhythmias. To evaluate this risk in cardiovascular disease-free subjects with cancer, ECG recorded at baseline, months 3, 6 and 12 fr...

Nipple-Areola Complex Reinnervation Using Intercostal Nerve Grafts in Implant-Based Reconstruction.

Despite successful aesthetic outcomes, immediate breast reconstruction is frequently accompanied by significant sensory loss, compromising patient quality of life. While neurotization techniques are established for autologous flaps, a standardized solution for implant-based recon...

Pelargonium graveolens and Pelargonium zonale as Valuable Sources of Antioxidants to Be Applied in Cosmetic Preparations

Pelargonium graveolens and Pelargonium zonale are promising sources of natural antioxidants and other bioactive compounds that may find future use in topical cosmetic preparations. The aim of our study was to investigate the antioxidant properties and chemical composition of extr...

Efficacy of dolutegravir or bictegravir-containing therapy in a real-life cohort of people with HIV-1 sub-subtype A6

OBJECTIVE: The objective of the study was to establish whether HIV-1 sub-subtype A6 (HIV-1A6) is a risk factor for virological failure in people with HIV (PWH) treated with the high genetic barrier integrase strand transfer inhibitors (INSTIs) dolutegravir (DTG) or bictegravir (B...

Associations of IL-2, IL-6 and IL-10 Gene Polymorphisms with Biochemical Parameters and Calcineurin Inhibitor Dosing in Kidney Transplant Recipients

Background/Objectives: Kidney graft dysfunction remains a major challenge limiting long-term transplant survival despite advances in immunosuppressive therapy. Cytokine signaling pathways have been implicated in the regulation of alloimmune responses and chronic inflammation, but...

Multi-Target Modulation of Interconnected Pathogenetic Pathways by Natural Bioactive Compounds in Endometriosis

Background: Endometriosis is a chronic estrogen-dependent disease characterized by the presence of endometrial-like tissue outside the uterine cavity. Its pathogenesis involves interactions between inflammatory, angiogenic, hormonal, oxidative stress-related, and cell survival-as...