Poltava State Agrarian University

From Molecular Design to In Vivo Validation: Integrated Efficacy and Safety Profiling of Orotic Acid–1,2,4-Triazole Hybrids with Wound-Healing Activity

Chronic and difficult-to-heal wounds require topical agents that combine reparative activity with favorable local disposition and an acceptable preliminary safety profile. This study evaluated three orotic acid–1,2,4-triazole hybrids (1–3) using an integrated computational and ex...