Pitzer College

ADNP ‐Related Helsmoortel–Van der Aa Syndrome: A Review of the Literature and Clinical Recommendations for Assessment and Monitoring

ABSTRACT ADNP‐related Helsmoortel–Van der Aa syndrome (ADNP‐related HVDAS) is a single gene form of autism spectrum disorder (ASD) caused by pathogenic sequence variants in the activity‐dependent neuroprotective protein ( ADNP ) gene. In addition to ASD, ADNP‐related HVDAS is ass...

Bridge positions of links that cannot be monotonically simplified

For any pair of integers $m$ and $n$ such that $3 < m < n$, we provide an infinite family of links where each link in the family has a locally minimal $n$-bridge position and a globally minimal $m$-bridge position. We accomplish this by applying the criterion of Takao et al. The...

Derivation of human post-mitotic cardiomyocytes from tetraploid iPSCs

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (iPS-CMs) have great potential in regenerative medicine. However, iPS-CMs are immature and resemble fetal cardiomyocytes, restricting their application. Fetal cardiomyocytes in the human heart are diploid and proli...