Institution
Pitié-Salpêtrière Hospital
Recent research
- Health & MedicineOpen access
Background: Structural brain changes during the earliest asymptomatic stages of Alzheimer's disease (AD) remain poorly understood. Previous research in preclinical AD shows heterogeneous findings, reporting both subtle neuronal loss and paradoxical increases in grey matter (GM) v...
- Health & MedicineOpen access
( Int J Gynaecol Obstet . 2026 Mar;172(3):1491–1500. doi:10.1002/ijgo.70421) A prospective observational study explored whether neurofilament light (NfL), a marker of neuronal injury, can be reliably measured in umbilical cord blood and whether it is associated with nonreassuring...
- Health & MedicineOpen access
Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...
- Health & Medicine
Background: Mastoid and epitympanic obliteration has become a widely used technique in cholesteatoma surgery to reduce postoperative recurrence. However, recurrent disease still occurs in some patients, and the anatomical sites and mechanisms of recurrence after obliteration rema...
- Materials & EnergyOpen access
ABSTRACT Isocitrate dehydrogenase (IDH) mutation and 1p/19q codeletion are key molecular markers for glioma classification. Amide proton transfer weighted (APTw) and nuclear Overhauser effect–weighted (NOEw) markers showed promise for glioma characterization, by probing protein‐r...
- BiologyOpen access
A dependency map enhanced with next-generation 3D cancer models
Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer1. The Cancer Dependency Map (DepMap) accelerates this field by systematically identifying cancer vulnerabilities in diverse preclinical models. Data from over...
- Health & Medicine
Maxens Decavèle, MD. PhD, Alexandre Demoule, MD. PhD; Listening to the Silent Patient: Toward Continuous Detection of Dyspnea During Mechanical Ventilation
- Health & Medicine
Importance: Capturing individual multiple sclerosis (MS) progression is difficult; few studies have evaluated glial fibrillary acidic protein (GFAP) in large longitudinal cohorts with independent validation. Objective: To investigate whether serum GFAP levels and treatment-relate...
- Health & MedicineOpen access
Bone metastases a represent a challenge in the oncological management of patients as the complications can be severe, as fractures or neurological impairment in spinal metastases. Recommendations on the management of bone metastases are constantly being improved. However, there a...