Physiologie de la Reproduction et des Comportements

Evolutionary dynamics and functional refinement of IGF bioavailability in the vertebrate phylum : focus on IGFBPs

In eutherians, Insulin-like Growth Factor-I (IGF-I) and IGF-II exert insulin-like activity by interacting with type-I receptor. IGF bioavailability is finely regulated by six IGF-Binding Proteins (IGFBPs), IGFBP-1 to -6, which bind IGF-I and -II with high affinity but not insulin...