Phoenix Children's Hospital

Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance

The gut microbiome has been implicated in the pathogenesis of food allergy (FA), prompting microbiome-focused interventions. We evaluated, in a phase 1 open-label trial (NCT02960074), the safety and efficacy of oral encapsulated fecal microbiome transplantation (FMT) in 15 adults...

Effect of time to palliative epilepsy surgery on outcomes

Abstract Objective Epilepsy duration is a modifiable risk factor in the outcome of definitive epilepsy surgery; however, an analogous effect in palliative procedures has not been shown. We reviewed the Pediatric Epilepsy Surgery Database data for an association between epilepsy d...

Optimizing Neurodevelopment in Infants With Severe Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) is associated with multiple morbidities, including neurodevelopmental impairment. This association is multifactorial and further complicated by prolonged hospital stays during a critical period of rapid brain growth. Despite the well-established l...