Phoenix Children's Hospital

What Factors Drive Female Surgeons to Change Jobs or Leave Medicine Altogether?

OBJECTIVE: To explore reasons female surgeons change jobs or leave medicine entirely. SUMMARY OF BACKGROUND DATA: Only a quarter of physicians in surgical specialties are female. Identifying reasons for career dissatisfaction is crucial to improve retention. METHODS: An anonymous...

Globalising the access to advanced molecular diagnostics of CNS tumors: Experience of the Molecular Neuro-Pathology (MNP) Outreach Consortium

Central nervous system (CNS) tumors pose a major global health challenge, particularly in low- and middle-income countries (LMICs), where outcomes remain disproportionately poor. The global CONCORD-3 study (Lancet Oncology) highlighted stark disparities in five-year survival (201...

Therapy‐Associated Lineage Switch and Clonal Evolution in Refractory NUP98 :: NSD1 ‐Rearranged Acute Leukemia

The authors declare no conflicts of interest. The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

Weight Gain Goals and Factors Associated With Readmission for Faltering Weight in Infants

OBJECTIVE: Infants hospitalized for faltering weight are a vulnerable population with limited evidence guiding inpatient management and weight gain targets. We examined associations of patient factors and weight gain target attainment with faltering weight-specific readmission an...

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

ABSTRACT Sepsis‐induced pediatric acute lung injury (ALI) and pediatric acute respiratory distress syndrome (PARDS) are life‐threatening conditions with high mortality rates and no current cure. Most ALI/ARDS studies focus on adults, albeit the pediatric population has unique cha...

Prescription Patterns of Cardiovascular Medications in the Adolescent and Adult Population With Fontan Circulation—A Report From the Multicenter Single Ventricle Outcomes Network

BACKGROUND: There are limited data on prescription patterns in adolescents and adults with Fontan circulation. METHODS: We conducted a retrospective analysis of patients 13 years of age and older enrolled between 2022 and 2024 in the Fontan Outcomes Network (now SV-ONE [Single Ve...

Does Race Influence Velopharyngeal Structure Size and Velar Stretch During Sustained Phoneme Production in Children?

Purpose: Differences in the size of velopharyngeal structures across racial groups at rest have been described in the literature, with race influencing adenoid thickness, pharyngeal depth, effective velar length, and velar length. The purpose of this study was to examine differen...

Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance

The gut microbiome has been implicated in the pathogenesis of food allergy (FA), prompting microbiome-focused interventions. We evaluated, in a phase 1 open-label trial (NCT02960074), the safety and efficacy of oral encapsulated fecal microbiome transplantation (FMT) in 15 adults...

Effect of time to palliative epilepsy surgery on outcomes

Abstract Objective Epilepsy duration is a modifiable risk factor in the outcome of definitive epilepsy surgery; however, an analogous effect in palliative procedures has not been shown. We reviewed the Pediatric Epilepsy Surgery Database data for an association between epilepsy d...

Optimizing Neurodevelopment in Infants With Severe Bronchopulmonary Dysplasia

Bronchopulmonary dysplasia (BPD) is associated with multiple morbidities, including neurodevelopmental impairment. This association is multifactorial and further complicated by prolonged hospital stays during a critical period of rapid brain growth. Despite the well-established l...