Phillips University

Psychological resilience as a key pathway between depression and executive functioning in epilepsy

Introduction In epilepsy, the burden of depression extends beyond mood, often accompanying difficulties in executive functioning. However, the psychological factors shaping this relationship remain largely unexplored. This study examines whether psychological resilience serves as...

Protein–protein interaction network architecture of human polygenic traits reveals domain-spanning connectivity and evolutionary pressures

Abstract Background Human polygenic phenotypes arise from the combined effects of many genes that interact within molecular networks. Yet, we know little about how the structure of these networks constrains or facilitates the evolution of complex traits. Here, we systematically e...

Factors for Success and Failure of Allergen Immunotherapy ( AIT ) Trial Design in the Light of Evidence‐Based Medicine: Current Aspects 2026

Allergen immunotherapy (AIT) has been acknowledged as the only disease-modifying treatment for respiratory diseases since its introduction in 1911. Although the efficacy and safety have convincingly been established in numerous randomized clinical trials (RCTs), the AIT study res...