Philip R. Lee Institute for Health Policy Studies

Percutaneous Coronary Intervention Facility Access and Clinical Outcomes Among Patients With Acute Myocardial Infarction

Importance The proliferation of percutaneous coronary intervention (PCI) facilities across the US has raised questions about whether expanding capacity improves outcomes in areas already served vs those without prior access. Objective To evaluate the association between the openi...

A stakeholder-engaged process to design and implement the Assessment of Cognitive Complaints Toolkit for Alzheimer’s Disease (ACCT-AD) in primary care

Background: Dementia is underdiagnosed, particularly in primary care settings where most people receive their healthcare. These is a need for tools to assist with the diagnosis of dementia by primary care clinicians, who greatly outnumber specialists. Objective: To describe the c...

Identifying optimal dose head CT acquisition techniques through cluster analysis from 904,209 scans

Abstract Objectives To identify clinically established and frequently utilized routine head computed tomography (CT) acquisition techniques in children and adults that achieve lower radiation. Materials and methods The level of the analysis is at the CT scan (series) level. CT ac...

Community-Based Surgery and Postoperative Survival Among Veterans Affairs Enrollees

Importance: The Veterans Affairs Maintaining Internal Systems and Strengthening Integrated Outside Networks (VA MISSION) Act of 2018 greatly expanded Veterans Affairs (VA) enrollees' access to non-VA (community care) services. Since then, community-based utilization has increased...

Evaluating large language model performance in US FDA regulatory science

Abstract Background Clinical and population decision-making relies on the systematic evaluation of extensive regulatory evidence. The FDA drug reviews provide detailed information on clinical trial design, enrollment criteria, sample size, randomization, comparators, endpoints, a...

Vitamin B deficiency and sarcopenia: an integrated narrative review of metabolic, inflammatory, endoplasmic reticulum stress, and myokine signaling pathways

Sarcopenia is an age-related skeletal muscle disorder characterized by progressive decline in muscle mass, strength, and physical performance, leading to frailty, disability, falls, and increased mortality. Although its pathogenesis is multifactorial, growing evidence indicates t...

Smoking cessation experiences during alcohol and cannabis treatment in substance use programmes in Catalonia: A qualitative study

Tobacco use remains disproportionately high among people receiving treatment for alcohol or cannabis use, yet it is rarely addressed in substance use services. This study explored the lived experiences of people who smoke while undergoing treatment for alcohol and/or cannabis use...