Philadelphia University

Sea Cucumber‐Inspired Double‐Network Biopolymer Hydrogels for Programmable Soft Machines

ABSTRACT Engineering biopolymer‐based hydrogels with robust load‐bearing capacity, reversible mechanical programmability, and adaptive actuation remains difficult due to weak physical crosslinking and porous structure. Inspired by the mutable dermis of sea cucumbers, a collagen–a...

INCREASED PREVALENCE OF PANCREATIC CYSTS IN NONSECRETOR (FUT2 NULL) INDIVIDUALS UNDER PANCREATIC SURVEILLANCE

Abstract Background: Pancreatic surveillance commonly detects pancreatic cysts, most of which are presumed intraductal papillary mucinous neoplasms (IPMN). FUT2, the gene responsible for secretor status, has been implicated in IPMN development, although not with pancreatic cancer...

Mechanics of electroadhesion by polycation interfacial bridging: sticky electrophoresis, ionic complexation and chain entanglement

Abstract An e-GLUE is a polymer network containing interpenetrating polycations, which can bond the anionic network of mucosa by polycation interfacial bridging under an electric field. This paper formulates a theoretical model to study such electroadhesion by electrophoresis of...

Women’s Attitudes toward the 2024 US Preventive Services Task Force Mammography Screening Guideline

Background: From 2009 to 2024, the US Preventive Services Task Force (USPSTF) recommended that women aged 40 to 49 y make an informed choice about when to begin having mammograms. In 2024, the USPSTF changed its guidelines, recommending biennial screening from age 40 to 74 y. Thi...

A miRNA-mediated gene regulatory network supports seasonal plasticity in the temperate coral Astrangia poculata

Phenotypic plasticity is critical for sessile marine invertebrates facing intensifying climate change. MicroRNAs (miRNAs)-small non-coding RNAs that regulate gene expression-are compelling candidates for mediating such plasticity, but their role in coral biology remains poorly ch...

What Can a Badge Do? A Pilot Study of the Vot-ER Badge in a Community Health Setting

Civic engagement is an important example of health and health care inequity in the United States, with voting being an active form of civic engagement that allows citizens to be involved in the political processes that directly impact their health. Existing literature indicates t...

Co-designing for social studies teacher learning: lessons from a six-year research−practice partnership

Purpose To date, little research examines what happens when co-design aims not at student-facing curriculum but, rather, at the development of teacher learning and professional development experiences. Given the success of co-design methods in promoting instructional innovation a...

Do Autistic Adolescents Talk Differently in Same-Sex Versus Mixed-Sex Conversations?

Autistic individuals often struggle with social communication, but the nature of each person’s difficulties varies substantially by context. Recent conversation-based research suggests that males and females (autistic and nonautistic) produce subtle but consistent differences in...

Assessing Value of Behavioral Interventions: Designing Cost-Effectiveness Analyses for Food-Is-Medicine Interventions

Food-is-Medicine (FIM) interventions, including medically tailored meals, medically tailored groceries, and produce prescriptions, represent a promising approach to prevent, manage, and treat diet-related diseases. As the evidence base for FIM interventions expands through large-...

Adaptive model-guided protein evolution with sparse data optimizes compact eukaryotic genome editors

Efficient protein engineering is constrained by vast sequence space and limited experimental throughput, particularly for protein families that lack large mutational datasets. Here we combine Fanzor2 (Fz2) ortholog discovery, ωRNA scaffold engineering and EvoMax, a model-guided p...

Engineering a biomimetic multiphasic suture anchor system for enhanced rotator cuff enthesis regeneration

Abstract Conventional suture anchor methods in rotator cuff repair often fail to replicate the native tendon-to-bone interface, leading to re-tears due to stress concentrations and poor biological integration at anchor sites. To address these challenges, we engineered a biomimeti...

Climate adaptation as evolvability

Abstract Standard approaches to climate adaptation, commonly understood as the protection of infrastructure, social systems, and ecosystems from adverse climate impacts, are too closely tied to the biological concept of adaptation and the ecological notion of stability . Instead,...

Eco-evolutionary feedback reshapes competitive dynamics in an orchard fly system

The feedback between competition and evolution is central to hypotheses about the origin and maintenance of species diversity. Yet, whether competition-induced evolution is sufficiently rapid, consistent, and strong to maintain diversity on ecological timescales remains unresolve...

Nuclear activities and interactome of the NS5 protein of tick-borne encephalitis virus

Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular pro...

Neurological Pupil Index and Outcome After Cardiac Arrest in Children: Single-Center, Retrospective Cohort, 2018–2023

OBJECTIVES: To determine the association between abnormal pupillary reactivity using automated infrared pupillometry and unfavorable outcome after pediatric cardiac arrest (CA). DESIGN: Single-center, retrospective, cohort study, 2018-2023. SETTING: Large tertiary PICU in the Uni...

SNAP Benefit Cycles and Antiretroviral Therapy Adherence Among Adults With HIV

This cohort study examines the association between timing of receipt of Supplemental Nutrition Assistance Program (SNAP) benefits and adherence to oral antiretroviral therapy among SNAP recipients with HIV.

A systematic review of environmental factors in AI-based fall risk prediction models for community-dwelling older adults

Falls commonly occur in home environments, where conditions can increase fall risk. Identification and mitigation of environmental hazards are critical components of fall prevention. However, artificial intelligence (AI)-based fall prediction models have largely focused on indivi...