Pharmaceuticals and Medical Devices Agency

Clearance of amino acids, trace elements, and carnitine during CRRT: the carnitine dichotomy

Continuous renal replacement therapy (CRRT) provides vital organ support in acute kidney injury but is associated with the inadvertent extracorporeal clearance of essential low-molecular-weight nutrients. While the loss of amino acids and trace elements is clinically recognized,...

Tracking regulatory convergence in Asia-Pacific Economic Cooperation (APEC): progress and gaps in key performance indicators

Abstract Purpose To assess progress in regulatory convergence among APEC economies using updated Key Performance Indicators (KPI) and to identify opportunities for strengthening reliance and work sharing, while informing future Phase 2 KPI development. Our work describes the adop...

Disproportionate expansion of radical prostatectomy among older men in Japan in the robotic surgery era: a nationwide descriptive time series analysis

Abstract Robot-assisted radical prostatectomy (RARP) has rapidly expanded and become the leading surgical approach for prostate cancer in Japan. However, it remains unclear whether the concurrent increase in radical prostatectomy reflects population aging, increased diagnostic ac...