Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research

Ex vivo JAK and TNF inhibitor–modulated immune signatures guide first-line therapy selection in rheumatoid arthritis

Background Rheumatoid arthritis (RA) is a heterogeneous autoimmune disease for which selecting the most appropriate first targeted therapy remains challenging. We integrated ex vivo immune-cell functional assays, targeted proteomics, clinical outcomes, and a three-dimensional (3D...

Vascular plasticity in the gastric cancer environment: mechanisms, prognostic significance, and concepts of therapeutic interventions

Gastric cancer (GC) remains a major global health problem because of its aggressive behavior and frequent development of therapeutic resistance. In GC, as in other malignancies, blood vessels are essential for Tumor-cell survival and dissemination, thereby facilitating metastasis...

Geographic Variation and Core Signatures of the Root Canal Microbiome: A Cross‐Country Comparative Study

AIM: Root canal infections harbour complex microbial communities that may vary across geographic populations. This study aimed to compare the root canal microbiome across Spain, Sweden, and the USA, identifying key microbial taxa, compositional and functional differences, and coh...

Endocannabinoid system dysregulation in oral diseases: mechanistic insights and therapeutic modulation

Abstract Background Chronic inflammatory and neoplastic diseases of the oral cavity, including periodontitis, oral lichen planus (OLP), oral squamous cell carcinoma (OSCC), and oral mucositis, represent a significant global health burden. Current therapeutic strategies face limit...

Cargo-specific platelet reprogramming and education mediated by pancreatic cancer-derived extracellular vesicles

The systemic progression of pancreatic ductal adenocarcinoma (PDAC) is tied to a hypercoagulable state, yet early tumor secretome–platelet interactions remain poorly defined. Prevailing models regard platelet education by tumor-derived extracellular vesicles (EVs) as a passive, d...

Clinical outcomes of stereotactic body radiotherapy in oligometastatic disease: a national real-world cohort study

Abstract Purpose We conducted the first multicentre Spanish real-world study assessing the efficacy and safety of stereotactic body radiotherapy (SBRT) in oligometastatic patients treated in routine clinical practice. Methods This retrospective, multicentre observational study in...

Identification of cellular double-stranded RNAs in mammalian embryonic stem cells

Abstract Antiviral defence mechanisms are typically activated upon sensing virus-derived nucleic acids. During replication, viruses generate double-stranded RNA (dsRNA) intermediates that the innate immune system can sense, triggering several defence pathways. Conversely, mammali...