People's Hospital of Xinjiang Uygur Autonomous Region

KSHV K15 genetic heterogeneity is associated with Kaposi sarcoma aggressiveness through modulation of the host inflammatory microenvironment

Kaposi sarcoma (KS) exhibits profound clinical heterogeneity, yet current risk assessment remains constrained by anatomical staging systems that lack universality across diverse KS variants. This study characterized the functional impact of Kaposi’s sarcoma-associated herpesvirus...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Integrated multi-omics analysis reveals the molecular landscape and therapeutic strategies in Chinese cervical cancer patients

Genomic or transcriptomic sequencing guides the precision of cervical cancer (CC) diagnosis; however, the molecular profile of Asian patients remains poorly understood. We established a comprehensive multi-omics cohort comprising 112 tumor-normal adjacent tissue pairs from Chines...

Comparison of efficacy and safety between unilateral biportal endoscopy and percutaneous endoscopic surgery for cervical spondylotic radiculopathy based on current evidence: a systematic review and meta-analysis

A systematic comparison of the clinical efficacy and safety between Unilateral Biportal Endoscopy (UBE) and Percutaneous Endoscopy (PE) in the Treatment of Cervical Spondylotic Radiculopathy (CSR). Computerized searches were conducted in PubMed, Cochrane Library, Web of Science,...

Targeting the immune microenvironment in Duchenne muscular dystrophy: roles of macrophages, eosinophils, regulatory T cells, and neutrophils

Duchenne muscular dystrophy (DMD) is a progressive, life-limiting muscle disease caused by dystrophin deficiency and characterized by recurrent myofiber necrosis, persistent inflammation, and fibrosis. Although dystrophin-restoring and disease-modifying therapies are advancing, n...

Evaluating the Precision of 3D Morphological Reconstruction for Asphalt Pavement Textures via Close-Range Photogrammetry

Accurate 3D reconstruction of pavement textures is vital for assessing surface performance. This study systematically evaluates the factors influencing the precision of close-range photogrammetry for pavement texture characterization. Four typical mixtures, AC-13, AC-16, SMA-16,...

Impact of dynamic blood glucose trajectories on mortality in critically ill non-traumatic intracranial hemorrhage patients: a retrospective cohort study

Dysglycemia is frequently observed in patients with non-traumatic intracranial hemorrhage (ICH) and has been linked to adverse clinical outcomes. However, the prognostic impact of longitudinal blood glucose trajectories in critically ill non-traumatic intracranial hemorrhage rema...

Stage-dependent activation of the circulating AIM2–caspase-1–GSDMD axis in silicosis: a cross-sectional study

Silicosis is a progressive occupational lung disease caused by long-term inhalation of crystalline silica, in which persistent inflammation contributes to lung injury and fibrotic remodeling. Experimental studies suggest that DNA-sensing pathways involving AIM2 may be engaged aft...

Latent multimorbidity patterns and their longitudinal associations with depressive symptom trajectories and ADL limitations among middle-aged and older adults in China: a longitudinal analysis of the CHARLS

Abstract Background Multimorbidity is heterogeneous, but longitudinal evidence from China on how specific disease patterns relate to changes in depressive symptoms and functional limitations remains limited. This study aimed to identify baseline multimorbidity patterns and examin...

Refining source-oriented ecological-health risk assessments of soil potentially toxic elements using region-specific geochemical baseline values in a high geological background region

Naturally mineralized regions exhibit elevated geochemical backgrounds of soil potentially toxic elements (PTEs). However, the use of uniform geochemical baseline values (GBVs) frequently leads to misclassification between natural enrichment and anthropogenic contamination, hinde...

FGF23 promotes atrial fibrillation susceptibility through ETV1‐dependent sodium channel regulation and calcium handling abnormalities

Abstract Fibroblast growth factor 23 (FGF23) is closely associated with atrial fibrillation (AF), yet whether it modulates sodium and calcium currents in atrial myocytes remains unclear. ETV1, a key transcription factor regulating atrial electrical conduction, may also be involve...

Demographic time bomb in COPD (1990–2050)

Chronic obstructive pulmonary disease (COPD) is a leading global cause of morbidity and mortality, characterized by irreversible airflow limitation and progressive symptoms. Despite declining age-standardized rates (ASRs), absolute burdens are rising due to population aging and g...

Latent profile analysis of postpartum depression symptoms and its associations with weight stigma and eating behaviors among postpartum women in China

Abstract Background Postpartum depression (PPD) represents a significant maternal health challenge with diverse symptom manifestations. Traditional analytical approaches that treat postpartum women as a homogeneous group may obscure distinct symptom patterns, limiting the develop...

Metabolic-extracellular matrix crosstalk in hepatocellular carcinoma: mechanisms and targeted intervention

Bidirectional crosstalk between metabolic reprogramming and extracellular matrix (ECM) remodeling in hepatocellular carcinoma (HCC) constitutes an important metabolic–ECM regulatory network that contributes to HCC progression. Metabolic derangements disrupt ECM deposition, crossl...

Cosmetic parameters associated with SRS-22r improvement postoperatively in patients with adolescent idiopathic scoliosis: a 2-year follow-up

Adolescent idiopathic scoliosis (AIS) significantly impacts physical appearance and quality of life. This exploratory study aims to investigate potential association between cosmetic parameters and minimal clinical improvement in SRS-22r scores at a 2-year follow-up in AIS patien...