People’s Hospital of Rizhao

Targeting an IL-17/IL-36 pathogenic hub in hidradenitis suppurativa with a bispecific antibody

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with a high unmet need, particularly for treatment-resistant tunnels. Integrated multiomics analysis revealed that HS tunnels are spatially organized, self-amplifying inflammatory circuits driven by synergistic...

HDAC11 and COMP Modulate Breast Cancer Cell Phenotypes and Osteoclastogenic Responses in a Co-culture Model

Background: Cartilage oligomeric matrix protein (COMP) interacts with stromal interaction molecule 1 (STIM1). Both COMP and histone deacetylase 11 (HDAC11) are highly expressed in breast cancer cells (BCC). Given the reported inhibitory effect of HDAC3 on COMP acetylation, HDAC11...

Delayed mechanical mitral prosthetic leaflet detachment with distal embolization and conservative management: a case report

Mechanical prosthetic valve leaflet detachment is an exceedingly rare but potentially fatal complication of valve replacement surgery, typically presenting with acute severe regurgitation and hemodynamic collapse. The underlying mechanisms remain incompletely understood, and mana...

UHPLC‐MS/MS‐Based Quantification of 14 Renshen Guben Oral Liquid–Related Constituents in Cancer Patients With Neutropenia

OBJECTIVES: This study aimed to develop and validate a UHPLC-MS/MS method for the simultaneous determination of 14 constituents related to Renshen Guben Oral Liquid (RSGB) in human plasma and to explore concentration-absolute neutrophil count (ANC) associations in cancer patients...

Synthesis of Bioactive Fluorinated 2-Heterocyclic Pyrrolidines via Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides

Abstract A copper-catalyzed asymmetric 1,3-dipolar cycloaddition of α-N-(heteroaryl-methyl)imines with gem-difluoroalkenes is reported. Using a Cu(I)/Segphos complex, this protocol provides diverse chiral fluorinated 2-heterocyclic pyrrolidines in high yields (up to 99%) with exc...

A Stepwise Correction Model for Operational Forecasting of Surface Soil Moisture During the Spring Sowing Period

Accurately predicting soil moisture conditions and determining the optimal sowing timing during the spring sowing period play a crucial role in ensuring high and stable grain yields. To address the limitations of existing soil moisture prediction models, i.e., the complexity and...

Qualitative study on the experience and needs of social isolation in older adults with stroke

Based on the Social Ecological Theory framework, this study aims to explore the social isolation experiences and needs of older adults with stroke, providing an empirical basis for constructing multi-level, systematic clinical intervention strategies. Using an interpretive phenom...