People's Hospital of Cangzhou

Efficacy and Safety of Crisugabalin for Inadequately Controlled Diabetic Peripheral Neuropathic Pain: A Randomized, Active‐Controlled, Phase 2 Trial

AIMS: Crisugabalin (HSK16149), a selective γ-aminobutyric acid (GABA) analog, has shown preliminary efficacy in controlling diabetic peripheral neuropathic pain (DPNP), but efficacy in patients with inadequate response to prior pregabalin treatment remains unknown. MATERIALS AND...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

The miR‑339‑3p/CIZ1 axis is associated with LPS‑induced microglial injury and sevoflurane‑associated cognitive impairment in aged rats

Postoperative cognitive dysfunction (POCD) substantially impairs the quality of life in elderly patients, but its underlying molecular mechanisms remain largely elusive. This study aimed to investigate miR‑339‑3p expression and its functional role in LPS‑induced microglial injury...

Redox Decoupling Modulates Multi‐Electron Reaction in Mn‐Rich NASICON Cathode for High‐Energy Sodium‐Ion Batteries

ABSTRACT Coupled redox reactions caused by voltage hysteresis limit the application of Mn‐rich NASICON cathodes for sodium‐ion batteries. Herein, this work fabricates a Na 3.6 Mn 1.25 Ti 0.7 Ni 0.05 (PO 4 ) 3 (NM1.25TP‐Ni) cathode material achieving redox decoupling of Mn/Ti. Spe...

Targeting Tc17 cell differentiation via the IL-6/JAK1/STAT3 signaling axis to attenuate immune checkpoint inhibitor-related colitis and promote tumor immunity

Immune checkpoint inhibitor-related colitis (IRC) is one of the most common immune-related adverse events, yet its underlying mechanisms remain unclear and treatments lack precision targeting. This study aims to elucidate the immune cell infiltration characteristics and regulator...

Conformation‐Locking in Thiazole‐Rich Mixed‐Linkage Covalent Organic Frameworks for Spontaneous Exciton Dissociation and Efficient Photocatalysis

ABSTRACT The formidable exciton effect inherent in organic semiconductors fundamentally restricts free charge carrier generation, thereby impeding photocatalytic redox efficiency. Facilitating spontaneous exciton dissociation and lowering exciton binding energy are essential for...

Factors associated with 30-day unplanned readmission after first-ever ischemic stroke: a retrospective cohort study in China

Unplanned readmission is an important post-stroke outcome, but clinically detailed data from Chinese cohorts remain limited. We evaluated the frequency of 30-day unplanned readmission after first-ever ischemic stroke and examined clinical factors associated with this outcome. We...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

AP-1-IL-1β signaling pathway on impulsive-like behavior and memory deficits in aged mice under tibial plateau fracture conditions

Tibial fracture surgery has attracted significant interest as a notable trigger for PND. Under external stimuli such as anesthesia and surgery, the transcription factor AP-1 regulates the abnormal expression of glutamatergic neurons via interleukin-1β (IL-1β), a mechanism closely...

Post-injury high-sensitivity C-reactive protein to lymphocyte ratio and nonunion risk in adult extremity fractures: evidence from a multicenter retrospective cohort

Early immuno-inflammatory response serves a critical role in the process of fracture healing, and both excessive and insufficient activation after injury may predict adverse outcomes. This study aimed to investigate the association between post-injury high-sensitivity C-reactive...