Peoples' Friendship University of Russia

Surgical treatment options for chronic complete traumatic ruptures of digital flexor tendons in dogs

The article describes the treatment results for four dogs with confirmed chronic complete ruptures of the deep and superficial digital flexor tendons.Surgical treatment involved exploration of the injury site, mobilization of the torn tendon ends, and end-to-end repair using a tw...

Panel-Specific Optimization and Benchmarking of Copy-Number Callers for ERBB2 Amplification Detection Using the Nanodigmbio NanOnco Plus Panel v3.0

Background/Objectives: ERBB2 amplification is a clinically relevant breast-cancer biomarker, but CNV detection from targeted sequencing depends on assay design, normalization, tumor fraction, and decision rules. We evaluated panel-specific ERBB2 analysis configurations against a...

Chronic Ultrasound (‘Emotional’) Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention

Background: Growing evidence supports a bidirectional relationship between ‘emotional’ (psychological) stress and intestinal inflammation. ‘Emotional stress’, a form of stress that is triggered by negative information and experiences of non-physical nature, is an established risk...

Regional Digitalization and Food-Service Industry Productivity: Evidence from Russian Regions

This study examines how different dimensions of the regional digital environment are associated with productivity in the food-service sector across Russian regions. Using regional panel data, the study distinguishes among digital infrastructure, digital platform adoption, online...

Zirconium-Mediated Modifications in SHS Shear Deformed TiAl(Nb,Mo)B Alloys: A Study of Phase Evolution and Mechanical Response

This work systematically examines the effect of zirconium additions on the phase transition behavior and microstructural evolution of TiAl(Nb,Mo)B systems subjected to shear deformation under unconstrained self-propagating high-temperature synthesis (SHS). The study further evalu...

Cytokine Profiles in Cervical Intraepithelial Neoplasia: Associations with Lesion Severity and Exploratory Treatment Response

Background: Persistent infection with high-risk human papillomavirus (hrHPV) is the principal cause of cervical intraepithelial neoplasia (CIN). Cytokines regulate antiviral immunity and tissue remodeling, and cytokine profiling may provide additional information about the biolog...

Asymmetric Metal-Templated Synthesis of Congested Proline Derivatives via [3 + 2] Cycloaddition Reaction

Abstract An asymmetric synthesis of congested proline derivatives with three defined carbon stereocenters (including two quaternary ones) through an Ag(I)-catalyzed [3 + 2] cycloaddition reaction is described. The atom-economic coupling of a chiral dehydroalanine Ni(II) complex w...

Macrophage Density Patterns in Uterine Leiomyomas Across Patient Age Groups: Evaluation of Separately Quantified CD68-Positive and CD163-Positive Cells

Tumor-associated macrophages (TAMs), key effectors of the innate immune system, actively participate in extracellular matrix remodeling, angiogenesis, and tumor growth. However, their age-associated quantitative and phenotypic distribution in uterine leiomyoma microenvironment re...

Artificial Intelligence as a Synergistic Driver of Contemporary Strategies for Accelerating Sustainable Development Processes: A Human Resource Perspective

The relatively slow pace of progress in achieving most of the objectives set forth in the 2030 Agenda for Sustainable Development (2030 Agenda) indicates a rather pessimistic outlook for their timely implementation. This, in turn, calls into question not only the attainment of th...

β‐myrcene: A nature‐identical compound for sustainable aquaculture

Abstract Sustainability is essential for the continued development of aquaculture. A key aspect of sustainable aquaculture involves using natural and organic compounds as alternatives to chemical counterparts. Herbal‐derived compounds have gained significant attention because of...

Comparative analysis of the strength of temporary bridge prostheses with different types of reinforcement framework under immediate load on dental implants

Relevance. Temporary plastic bridge prostheses supported by dental implants, used in immediate loading protocols, often fail due to fracture of the internal reinforcing framework. The optimal configuration of a 1 mm diameter titanium wire framework remains unclear. Objective — to...

Geographic Patterns of Pancreatic Cancer Mortality and Dietary Microplastic Exposure in Italy: An Ecological Hypothesis-Generating Framework

Pancreatic cancer (PC) mortality in Italy exhibited a persistent North–South macro-geographic gradient between 2003 and 2022, with significantly higher rates in northern regions. Whilst traditional risk factors partially explain this trend, the contribution of emerging dietary xe...

Management of metastatic spinal disease in low- and middle-income countries: an international survey of practices and challenges in Latin America

Spinal metastases impose urgent diagnostic and therapeutic demands; however, evidence from low- and middle-income countries (LMICs) in Latin America is sparse. We aimed to characterize real-world practices, access gaps, and priorities to in-form context-adapted guidelines. We con...

Investigation of the Torsion Strength of Basalt Fiber Reinforced Expanded Clay Lightweight Concrete Beam

This study explores the torsional behavior of lightweight expanded clay concrete beams reinforced with basalt fibers (BF) using finite element analysis, highlighting the importance of reinforcement type in improving torsional performance, focusing on basalt rebars, steel rebars,...

Cellulose acetate nanocomposite membranes for efficient textile dye removal

Abstract Large-scale dye discharge from the textile industry remains a major environmental concern, with substantial quantities released into wastewater streams each year. In this research, cellulose acetate (CA) nanocomposite membranes incorporating layered double hydroxides (LD...

Synergy of Phenylsilsesquioxane and Pyridylpyrazolate Ligands in Hexacopper Cages: Approach to Catalytic Toluene Oxidation

Abstract Cage-like Cu6M2 (M = Li or Na) complexes, containing two pairs of ligands, Si5-cyclic silsesquioxanes and pyrazolylpyridines, have been obtained. Two central (Cu···Cu···Cu···M) tetramers are sandwiched by Si ligands, while pyrazolylpyridines behave simultaneously in chel...

Nonlinear Responses of Anaerobic Methane Oxidation to Water Table Drawdown in Peatlands

Abstract Anaerobic oxidation of methane (AOM) serves as a key methane (CH4) sink that attenuates methane emissions from peatlands. Climate change has induced widespread water table drawdown in peatlands, but the response of AOM to the water table depth (WTD) and the temperature s...

The influence of physical, respiratory, and vocal exercises on the acoustic characteristics of the voice of professional vocalists

The article examines the impact of functional tests on the acoustic characteristics of professional singers. Particular attention is paid to an objective analysis of changes in the main acoustic parameters before and after performing exercises. OBJECTIVE: To identify and characte...

4-Oxo-7-Halosubstituted Phenanthroline Diamides Bifunctional Reactivity: A Synthetic Pathway to Unsymmetrical Polydentate Ligands

An efficient approach to unsymmetrical 1,10-phenanthroline-2,9-dicarboxamides based on the bifunctional reactivity of 4-oxo-7-haloderivatives is reported. These substrates exhibit orthogonal reactivity, enabling selective nucleophilic aromatic substitution at the C7 position alon...

Efficacy of Low Dose of Dihydroquercetin (DHQ) in Two Genetic Models of Neurodegeneration: Insights from FUS[1-359]-Tg and APPswe/PS1dE9 Paradigms

Dihydroquercetin (DHQ), a powerful antioxidant and regulator of cellular metabolism, was proposed for therapy of neurodegenerative disorders. Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS) are serious neurodegenerative disorders with oxidative stress as an overl...