People 's Hospital of Jilin Province

Breaking the Lipid Bottleneck: A Mitophagy‐Driven Nanoregulator Amplifies Ferroptosis for Colorectal Cancer Immunotherapy

ABSTRACT Colorectal cancer (CRC) therapy is severely constrained by the immunosuppressive tumor microenvironment (TME). This study presents a TME‐responsive nanometabolic regulator, ZnO 2 @Fe@HA (ZFH), designed to bridge mitochondrial dysfunction, lipid reprogramming, and ferropt...

Early renal perfusion phenotypes and renal recovery in critically ill patients with or at risk for acute kidney injury: a prospective multicenter cohort study

BACKGROUND: Acute kidney injury (AKI) in critical illness is heterogeneous, and conventional Kidney Disease: Improving Global Outcomes (KDIGO) classification may not capture early physiologic differences relevant to renal recovery. METHODS: Critically ill adults with or at risk f...

Sitting Time and Physical Activity Correlate With Asthma Exacerbations in Adults: A Cross‐Sectional Study From the Australasian Severe Asthma Network

Summary Lower levels of sitting time were associated with a lower risk of severe asthma exacerbations in adults. High levels of physical activity eliminated the detrimental association of sitting time with severe asthma exacerbations in adults.