Pennington Biomedical Research Center

Shared Genetic and Regulatory Architecture of Congenital Heart Disease and Autism Spectrum Disorder Revealed by Cross-Tissue Multi-Omic Integration

Background: Congenital heart disease (CHD) and autism spectrum disorder (ASD) co-occur more frequently than expected, suggesting shared developmental susceptibility. We aimed to identify cross-tissue molecular candidates linking cardiac and neurodevelopmental abnormalities. Metho...

Home-based digital exercise versus hospital physiotherapy for plantar fasciitis: a propensity-score-matched retrospective cohort study with dual-perspective cost-utility evaluation

OBJECTIVE: To compare the clinical effectiveness and cost-effectiveness of a 12-week home-based digital exercise programme with 12-week hospital-supervised physiotherapy for plantar fasciitis in routine Chinese tertiary-hospital care. DESIGN: Single-centre retrospective cohort st...

Household Poverty and Movement Behaviors in Preschool Children: A Longitudinal Study of Physical Activity, Screen Time, and Sleep

Background: Household poverty may shape physical activity (PA), screen time, and sleep during early childhood, but longitudinal evidence among preschool-aged children remains limited. This study examined longitudinal associations between household poverty status and these movemen...

Tibial Bone Shape Is Sport Dependent and More Symmetrical in High-Impact Athletes: A Cross-Sectional Study

Introduction: Multidirectional sports introduce unique forces to the tibia that potentially induce more symmetrical distribution of bone mass and lower bone stress injury risk, when compared to unidirectional sports. Purpose: To compare tibial shaft size, shape, and estimated str...

Tackling Waste of Fruits and Vegetables in Chilean Households with Tailored Informational–Enablement Interventions: A Randomized Controlled Pilot Study

Randomized Controlled Trials (RCTs) and direct measurement of waste are the gold standards for evaluating food waste interventions. This pilot RCT explored the effects of a 3-week tailored informational–enablement intervention to reduce the causes and amount of fruit and vegetabl...

FGF21-dependent and -independent liver transcriptomic adaptations to low-protein feeding during aging

Aging is a risk factor for the development and progression of metabolic impairments. Dietary protein restriction (DPR) is protective against obesity- and age-related metabolic decline by the induction of the fibroblast growth factor (FGF21), which regulates body weight, lipid han...