Peking University School and Hospital of Stomatology

Associations Between Oral Frailty Patterns and Depressive Symptoms in Older Adults: A Multicenter Cross‐Sectional Latent Class and Association Analysis

ABSTRACT Background Oral frailty is a comprehensive indicator of age‐related oral decline, yet its heterogeneity and association to depression are poorly understood. We aimed to identify latent classes of oral frailty and evaluate the association between dietary diversity and dep...

Femtosecond laser photoporation enables efficient delivery of apoptotic vesicles for enhanced osteogenesis

Abstract A major barrier to the translation of vesicle-based therapeutics in regenerative medicine is the ability to achieve efficient intracellular delivery without compromising, and ideally amplifying, biological activity. As a bioactive class of cell-derived vesicles with pro-...

SCFJFK regulates osteoblast differentiation through targeting RUNX2

RUNX2 (Runt-related transcription factor 2) is a master regulator of osteogenesis, and its genetic mutations are associated with ~65% cases of cleidocranial dysplasia (CCD), an autosomal dominant abnormal bone development disorder in humans with defective intramembranous bone for...

Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology

Orthodontic treatment corrects various craniofacial malformations primarily through triggering active alveolar bone remodeling, however the potential impacts of this intervention on the systemic immune state have long been insufficiently explored. Here, we show that mechanical fo...