Peking University Sixth Hospital

Visual snow syndrome as a neuropsychiatric network disorder: clinical features, mechanisms, and therapeutic perspectives

Abstract Visual Snow Syndrome (VSS) is a neurological condition characterized by the persistent perception of dynamic, flickering, dot-like visual disturbances across the entire visual field, resembling television static. Increasing evidence indicates that VSS is frequently accom...

The mediating role of brain structural-functional connectivity coupling in linking paternal education to BMI and depressive scores in young adults

Parental education is associated with body mass index (BMI), mental health, and neurodevelopment in young adults, yet the neurobiological mechanisms remain unclear. This study investigated whether parental education is related to BMI and depressive scores through brain structural...

Association Between Lithium Use and Suicide‐Related Behaviors in Bipolar Disorder: A Multicenter Study

BACKGROUND: Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real-world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized. METHODS: In...

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dent...