Peking University Shenzhen Hospital

Cardiomyocyte-Specific LncRNA CSTPP Prolongs the Proliferation Window by Promoting CDKN1A Decay in Postinfarction Cardiac Regeneration

BACKGROUND: Adult mammalian cardiomyocytes exhibit some capacity to reenter the cell cycle after ischemic injury. However, activated cardiomyocytes rapidly undergo cell cycle rearrest shortly after activation. Long noncoding RNAs (lncRNAs) have emerged as critical regulators of c...

Experimentalist Governance in Food Democracy: Monitoring and the Right to Food in Selected Chinese and European Cities

ABSTRACT Cities have become the level at which the right to food is either operationalized or left abstract, yet we have little comparative vocabulary for describing how they do it. This article examines local food observatories and monitoring mechanisms in four cities, namely, S...

Integrated Proteomic and Phosphoproteomic Profiling Reveals Dysregulated Inflammatory Signaling Networks in Rheumatoid Arthritis

Aberrant protein phosphorylation orchestrates sustained inflammatory immune signaling in rheumatoid arthritis (RA), yet the coordinated remodeling of proteomic and phosphoproteomic landscapes in peripheral blood mononuclear cells (PBMCs) remains poorly resolved via system-level m...

Circulating and tumor microenvironment immunomarkers associate with immunotherapy efficacy in advanced bladder urothelial carcinoma: an exploratory multicenter study integrating genomic and immunophenotypic profiling

Aims To elucidate the efficacy-predictive values of immunomarkers in both peripheral blood and tumor tissue in patients with advanced bladder-urothelial-carcinoma (aBUC) undergoing first-line immunotherapy.Patients and methods In previously untreated aBUC, T-cell subclusters and...

Multi-gate organic dendritic transistors for spatiotemporal BCM learning

The Bienenstock–Cooper–Munro (BCM) learning rule effectively mitigates the issue of synaptic weight oversaturation in Hebbian learning via a sliding threshold dependent on historical neuronal activity. However, existing hardware implementations focus primarily on temporal history...

D-allose reprogrammes the mitophagy–mtDNA–cGAS–STING–ADM2 axis to restore nucleus pulposus cell homeostasis in intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is driven by progressive loss of nucleus pulposus cell (NPC) homeostasis, yet the stress-responsive mechanisms governing this process remain incompletely defined. Here, we identify a mitochondrial stress-innate immune signalling axis in whi...

The efficacy of concurrent chemoradiotherapy with or without nimotuzumab in high‐risk patients with locally advanced head and neck squamous cell carcinoma post‐surgery: A real‐world study

Abstract Purpose Patients with locally advanced head and neck squamous cell carcinoma (LA‐HNSCC) harboring high‐risk pathological features after radical surgery face high recurrence rates. This real‐world study evaluated the efficacy and safety of concurrent chemoradiotherapy (CC...

Intramolecular Dearomative [2 + 2] Cycloadditions of (Hetero)arenes Utilizing an Energy-Transfer Organic Photocatalyst

Abstract Expanding the application scope of organic photoredox catalysts is of considerable importance in photocatalysis. Herein, we report an energy transfer (EnT)-mediated intramolecular dearomative [2+2] cycloaddition of N-substituted-N-(2-arylallyl)-2-naphthamides, N-acryloyl...

A Sequence-to-Scaffold Platform Enables Programmable Carrier-Supported Biocatalysis for Nucleoside Analog Synthesis

Abstract Industrial biocatalysis increasingly requires strategies that convert enzyme discovery into robust catalyst systems for process implementation. Here, we report Spatially Programmable Assembly of Computationally Mined Enzymes (SPACE), a sequence-to-scaffold workflow coupl...

Factors influencing healthcare providers’ adoption of artificial intelligence-based clinical decision-support systems: a systematic review using the CFIR framework

Artificial intelligence-based clinical decision-support systems (AI–CDSS) are increasingly used in healthcare, but their adoption by healthcare providers (HCPs) remains challenging. Reported determinants span technological, organizational, individual, and implementation-related l...

scTransMIL bridges patient-level disease states and single-cell transcriptomics for cancer screening and heterogeneity inference

Single-cell sequencing offers profound insights into tumor complexity. However, reliably linking individual cellular profiles to overall sample-level phenotypes remains computationally challenging, particularly when cell-specific annotations are absent. This disconnect limits the...

Mechanism-Constrained Learning for Regime-Aware Urban Ozone Prediction and Interpretation

Abstract Accurately characterizing source-related and precursor factors associated with surface ozone (O3) pollution remains a central challenge for air quality management. Data-driven models can achieve strong predictive performance, but mechanistically consistent interpretation...

Decoupled Synthesis Pathway via Precursor Functionalization Stabilizes High‐Voltage Nickel‐Based Cathodes

ABSTRACT Nickel‐based layered cathodes are promising candidates for high‐performance, high‐energy lithium‐ion batteries, yet their high‐voltage application is jointly limited by synthesis‐inherited structural defects and an unstable lattice oxygen framework. Here, we show that bo...

PANoptosis-related HLTF promotes prostate cancer progression and serves as a potential therapeutic target

Accumulating evidence indicates that pan-apoptosis plays a significant role in tumour progression, highlighting the importance of determining its relevance to tumour prognosis and treatment. This study aims to classify the molecular patterns of pan-apoptosis and explore the molec...

A fully automated deep learning pipeline system for carotid plaque segmentation and vulnerability classification on multi-contrast MRI: a multicenter study

Abstract Background Carotid vulnerable plaque rupture is a major cause of ischemic stroke. However, accurate identification of high-risk plaques using medical images heavily relies on radiologists’ expertise. This study aimed to develop an artificial intelligence (AI) system for...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

Efficacy and Safety Analysis of Single‐Port Robotic Assisted Cholecystectomy Using a Novel Surgical Platform: A Bicentre, Single‐Arm, Prospective Phase II Clinical Study

ABSTRACT Background Single‐port robotic cholecystectomy offers minimally invasive benefits. This trial evaluated the feasibility and safety of a novel system, MicroPort SA‐1000. Methods In this dual centre, single‐arm, prospective study, eligible patients underwent single‐port ro...

scProtoTransformer: Scalable reference mapping across molecules, cells, and donors

Abstract The rapid accumulation of single-cell data has made it possible to comprehensively characterize biological systems at molecular, cellular, and donor levels. However, scalable reference mapping across different resolutions remains a major challenge in current research. He...

Association of Antibiotic Exposure with Survival Outcomes in Patients with Advanced KRAS-Mutated NSCLC Receiving Immune Checkpoint Inhibitors

Background: Antibiotic exposure has been associated with reduced benefit from immune checkpoint inhibitors (ICIs) in patients with non-small cell lung cancer (NSCLC). However, evidence in patients with KRAS-mutated NSCLC remains limited. This study evaluated the associations of a...

Papillary urothelial neoplasm of low malignant potential: real-world diagnostic pitfalls and clinical outcomes from a case series

Papillary urothelial neoplasm of low malignant potential (PUNLMP) is an uncommon non-muscle-invasive bladder tumor. Its indolent nature often leads to underestimation of diagnostic complexity and recurrence risk, particularly in real-world practice where pathological distinction...